Primary pulmonary lymphoepithelioma-like carcinoma in non-endemic region: A case report and literature review

Medicine
Chao XieJing Huang

Abstract

Pulmonary lymphoepithelioma-like carcinoma (LELC) is a rare type of lung squamous cell carcinoma. In situ hybridization test for Epstein-Bar virus-encoded RNA (EBER) is generally used for distinguishing it from other lung cancers. Although plasma EBV DNA quantification has been widely used as a tumor biomarker in nasopharyngeal carcinoma (NPC), only a limiting number of studies have suggested that plasma EBV DNA quantification may be used as a tumor marker in pulmonary LELC patients. We report two female patients diagnosed as poorly differentiated squamous cell carcinoma, subsequently, their further histological examinations showed that tumor cells were EBER positive and plasma EBV DNA was detectable. Two patients was diagnosed with advanced pulmonary LELC. The patients were treated with chemotherapy and chemoradiotherapy respectively. Both patients responded well to our treatment, in accordance with their decreased EBV DNA level. Pulmonary LELC is a rare type of lung cancer which is sensitive to chemoradiotherapy, especially in late staged patients.

References

Mar 15, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Issan Yee San TamMaria P Wong
Apr 25, 2006·AJR. American Journal of Roentgenology·Joseph M HoxworthMichael B Gotway
Jan 27, 2009·Cancer·Daisy Wing-Sze WongUNKNOWN University of Hong Kong Lung Cancer Study Group
Mar 3, 2009·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Jose Javier Gómez-RománJose Fernando Val-Bernal
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Dec 3, 2014·Experimental and Therapeutic Medicine·Rui LiangWan-Pu Wang
Mar 20, 2016·Interactive Cardiovascular and Thoracic Surgery·Zhichao LinJianxing He

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Citations

Jun 5, 2020·OncoTargets and Therapy·Yan HuWenliang Liu
Feb 3, 2021·International Journal of Surgery Case Reports·Akihiro SasakiMitsuhito Kaji

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Methods Mentioned

BETA
biopsy
surgical resection

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