Primary pulmonary lymphoepithelioma-like carcinoma

Medical Oncology
Ying FanHongyang Lu

Abstract

Primary pulmonary lymphoepithelioma-like carcinoma (PPLELC) is an extremely rare subtype of non-small-cell lung cancer (NSCLC) but differs from other NSCLC types. Most patients with PPLELC have almost no obvious clinical manifestations, and are often diagnosed in the advanced stage. Complete resection is the standard treatment for cases with early stage disease, while chemotherapy and radiotherapy are effective to some extent in late stage disease. High expression of PD-L1 in PPLELC tumor cells confers immunotherapy an important role in the treatment of PPLELC, and programmed death-1 (PD-1) inhibitors such as nivolumab and pembrolizumab may be optimal options for PPLELC patients. This review focuses on the clinical and pathologic features, treatment, and prognosis of PPLELC.

References

Aug 1, 1989·The American Journal of Surgical Pathology·A E ButlerC Lombard
Dec 1, 1987·Journal of Surgical Oncology·L R BéginL Panasci
Aug 15, 2000·American Journal of Clinical Pathology·A J HanY S Zong
Nov 4, 2000·Respiratory Medicine·J C HoK W Tsang
May 23, 2002·The American Journal of Surgical Pathology·Yih-Leong ChangYung-Chie Lee
Jan 30, 2004·Journal of Virology·Wen-hai FengShannon C Kenney
Aug 19, 2006·Respirology : Official Journal of the Asian Pacific Society of Respirology·James C HoWah K Lam
Sep 19, 2007·The British Journal of Radiology·Chung-Jen HuangHorng-Chyuan Lin
Jun 24, 2008·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Ta-Chiang LiuChao-Jung Tsao
Aug 26, 2009·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·James C HoWah K Lam
Mar 23, 2012·Nature Reviews. Cancer·Drew M Pardoll
Jun 9, 2012·The Journal of Physiological Sciences : JPS·Philip J DerbyshireSeamus P J Higson
Nov 5, 2013·The Annals of Thoracic Surgery·Min-Shu HsiehYih-Leong Chang
Aug 3, 2014·The Annals of Thoracic Surgery·Yung-Han SunKuan-Jeng Chen
Jan 7, 2015·Chest·Brandon S GrimesIgor Barjaktarevic
Apr 12, 2015·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Yih-Leong ChangPan-Chyr Yang
Aug 21, 2015·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·William D TravisUNKNOWN WHO Panel
Sep 29, 2015·The New England Journal of Medicine·Hossein BorghaeiJulie R Brahmer
Feb 6, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Joanna H TongKa F To
Mar 20, 2016·Interactive Cardiovascular and Thoracic Surgery·Zhichao LinJianxing He
Apr 20, 2016·JAMA : the Journal of the American Medical Association·Antoni RibasCaroline Robert
Oct 18, 2016·Journal of Thoracic Disease·Wen-Yang JiangHeng Zhao
Dec 2, 2017·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Mian XieXiaoxiang Li
Apr 29, 2018·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Ankit AnandStephen Graziano
Jan 27, 2019·Clinical Lung Cancer·Anand NarayananJonathan W Riess
Oct 1, 2019·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Zuan LinShaodong Hong

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