Primary Rhabdomyosarcoma of the Breast: Study of Three Cases at One Institution with a Review of Primary Breast Sarcomas

Journal of Pathology and Translational Medicine
Junyoung ShinKyung-Ja Cho

Abstract

Primary breast sarcoma (PBS) is rare, comprising approximately 1% of breast malignancies. Rhabdomyosarcoma (RMS) accounts for an extremely small proportion of PBSs, often leading to delayed histologic confirmation. Upon reviewing Asan Medical Center's pathology database between 2000 and 2018, 41 PBS cases were retrieved, including three cases of primary RMS of the breast. Their clinicopathological features were analyzed, and the literature related to PBS and primary RMS of the breast was reviewed. We identified three primary breast RMS cases from our institution database, comprising 7.3% of PBS: one case each of spindle cell/sclerosing RMS (ssRMS), alveolar RMS (aRMS), and embryonal RMS (eRMS). All cases involved adolescents or young adults (14, 16, and 25 years, respectively) who underwent mastectomy or radiotherapy and were confirmed using immunohistochemical testing for myogenin, desmin, and myogenic differentiation. The ssRMS patient experienced recurrence at the operation site 4 months post-surgery despite undergoing concurrent chemoradiotherapy. The aRMS patient had multiple metastases at diagnosis and showed FAX3-FOXO1 fusion transcripts; she died 22 months after the diagnosis. The eRMS patient had enlarged axillary lymp...Continue Reading

References

Nov 5, 1998·Journal of Pediatric Surgery·L J Herrera, H Lugo-Vicente
Dec 4, 2003·European Journal of Radiology·F BinokayE Aksungur
Dec 23, 2003·Best Practice & Research. Clinical Endocrinology & Metabolism·Sacha J HowellAnthony Howell
May 6, 2005·The Breast Journal·Antoine ItalianoAntoine Thyss
Sep 13, 2005·Clinical Imaging·Fabien DaussePascale Leblanc-Talent
Aug 4, 2010·Cytopathology : Official Journal of the British Society for Clinical Cytology·A RasinariuP Vielh
Oct 1, 2007·The Indian Journal of Surgery·Venkata Satya Suresh AttiliG Anupama
Nov 17, 2012·Journal of the International Neuropsychological Society : JINS·Lyla E HamptonMaureen Dennis
Jul 23, 2013·The American Journal of Case Reports·Suresh J BhosaleSanjitsingh R Sulhyan
Oct 12, 2013·Advances in Anatomic Pathology·David M Parham, Frederic G Barr
Dec 3, 2014·International Journal of Surgery Case Reports·Abdulmalik Altaf, Hager Aref
Jan 6, 2016·Journal of Clinical Pathology·Sue Zann LimPuay Hoon Tan
Apr 6, 2016·Journal of Indian Association of Pediatric Surgeons·Nizamudheen M PareekuttySajid S Qureshi
Jun 10, 2016·International Journal of Surgery Case Reports·Nuria LiRafael Fabregas
Nov 24, 2016·Journal of Pediatric Hematology/oncology·Anthony N AudinoNicholas D Yeager
Aug 11, 2017·Cancer Biology & Therapy·Yufen YuanYunbao Pan
Dec 17, 2017·Medicine·Do Young KimYoung Jin Choi
Oct 16, 2018·Breast Care·Zuhal BayramogluIbrahim Adaletli

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy
SMA
dissection

Related Concepts

Related Feeds

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.