Primary Role of Mitochondria and Calcium Ions in the Induction of Reactive Oxygen Species by External Stimuli such as Triorganotins

Toxicology in Vitro : an International Journal Published in Association with BIBRA
E CorsiniC L Galli

Abstract

Tributyltin (TBT) salts are potent skin irritants both in humans and rodents. Data in the literature indicate mitochondria as target of TBT effects. The purpose of this study was to investigate the early intracellular molecular events that follow TBT treatment and mitochondrial impairment and the relevance of mitochondria in gene-regulatory signalling pathways. The results obtained indicate the pivotal role of Ca(2+) as the starting event following TBT treatment and confirm the important role of mitochondria as the source of second messenger molecules essential for TBT-induced NF-kappaB activation and IL-1alpha production.

References

Apr 1, 1992·International Journal of Immunopharmacology·M J Fenton
Jan 1, 1990·Cytokine·K Muegge, S K Durum
May 1, 1991·Molecular and Cellular Biology·Y DevaryM Karin
Dec 1, 1990·The Journal of Clinical Investigation·T S Kupper
Dec 1, 1987·Environmental Research·N J SnoeijW Seinen
Jan 1, 1994·Annual Review of Immunology·P A Baeuerle, T Henkel
Nov 30, 1993·Annals of the New York Academy of Sciences·M IlnickaE M Eugui
Nov 30, 1993·Annals of the New York Academy of Sciences·S W Lee, M Ilnicka
Jun 1, 1996·Toxicology and Applied Pharmacology·E CorsiniC L Galli
Nov 1, 1996·The Journal of Investigative Dermatology·E CorsiniC L Galli
Jun 1, 1994·Toxicology in Vitro : an International Journal Published in Association with BIBRA·E CorsiniC L Galli

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Citations

Dec 17, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Ahmed M Osman, Henk van Loveren

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