Primary Sclerosing Cholangitis with Inflammatory Bowel Disease in Korean Children

Pediatric Gastroenterology, Hepatology & Nutrition
Jisun YoonKyung Mo Kim

Abstract

Primary sclerosing cholangitis (PSC) is a rare condition that can be associated with inflammatory bowel disease (IBD). The aim of this study was to evaluate PSC and its association with IBD in children. We retrospectively enrolled 13 pediatric patients (<18 years) with PSC treated at Asan Medical Center between June 1989 and December 2013. Clinical findings and long-term outcomes were investigated. During the same period, the incidence of PSC among IBD patients was evaluated among 600 Crohn disease (CD) and 210 ulcerative colitis (UC) patients. All 13 study patients diagnosed with PSC also presented with IBD. Eleven boys and two girls with a median age of 15.0 years old (9.0-17.8 years) were included. The cumulative incidence of PSC for UC was 5.7% (12 of 210) and 0.2% for CD (1 of 600), respectively. PSC occurred during follow-up for IBD for five patients (38.5%) whereas, IBD developed during follow-up for PSC for two patients (15.4%), and was diagnosed during the initial work-up for PSC for 6 patients (46.2%). For the 77.3 month median follow-up period, 9/13 patients (69.2%), neither the clinical symptoms nor blood test results worsened. Two cases (15.4%) developed liver cirrhosis and underwent liver transplantation. Among 13...Continue Reading

References

Nov 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·U BrooméL S Eriksson
Oct 11, 2001·Journal of Pediatric Gastroenterology and Nutrition·W A FaubionJ Perrault
Jun 28, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ariel E FeldsteinPaul Angulo
Feb 24, 2006·Seminars in Liver Disease·Ulrika Broomé, Annika Bergquist
Feb 23, 2007·The American Journal of Gastroenterology·Gilaad G KaplanSamuel S Lee
Feb 5, 2008·Clinics in Liver Disease·Diego Vergani, Giorgina Mieli-Vergani
Jan 6, 2009·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Tamir MilohNanda Kerkar
Feb 10, 2010·Gastroenterology·Francis A FarrayeUNKNOWN AGA Institute Medical Position Panel on Diagnosis and Management of Colorectal Neoplasia in Inflammatory Bowel Disease
Aug 27, 2010·Journal of Hepato-biliary-pancreatic Sciences·Hitoshi SanoTakashi Joh
Oct 8, 2011·Diseases of the Colon and Rectum·Lina LindströmAnnika Bergquist
May 21, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Mark DeneauStephen L Guthery
Mar 20, 2015·Current Gastroenterology Reports·Saira A Khaderi, Norman L Sussman
Apr 14, 2015·Scandinavian Journal of Gastroenterology·Erik SchrumpfTom H Karlsen
Apr 15, 2015·The American Journal of Gastroenterology·Keith D LindorUNKNOWN American College of Gastroenterology

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Citations

Apr 9, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Mark R DeneauM Kyle Jensen
Feb 23, 2018·Journal of Pediatric Gastroenterology and Nutrition·Harveen SinghPeter Lewindon
Aug 14, 2019·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Shuichiro UmetsuTomoo Fujisawa
Feb 1, 2017·Journal of Pediatric Gastroenterology and Nutrition·Henry ShiauRichard Kellermayer
Mar 30, 2018·Current Gastroenterology Reports·Amanda RicciutoAnne M Griffiths
Jul 21, 2020·World Journal of Hepatology·Tej I MehtaJames H Tabibian
Jul 23, 2021·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Angelo Di GiorgioGiorgina Mieli-Vergani

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Methods Mentioned

BETA
biopsy

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