PMID: 9421097Jul 1, 1997Paper

Primary serous papillary adenocarcinoma of the vagina: a case report

International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists
C RivaC Capella

Abstract

The first reported case of vaginal serous papillary adenocarcinoma (VSPA) in a 61-year-old woman is presented. The woman had a mass in the upper posterior vaginal wall that was 2.5 cm in maximal dimension and was treated with a radical hysterectomy with bilateral salpingo-oophorectomy, lymphadenectomy, and subtotal vaginectomy, followed by radiation therapy. The ovaries, fallopian tubes, cervix, endometrium, and peritoneum did not show primary or secondary neoplastic involvement. The patient died because of recurrent disease in the form of widespread peritoneal metastases 30 months postoperatively. Microscopically, the tumor was similar to serous papillary adenocarcinoma of the ovary (OSPA). Immunohistochemical studies showed positive staining for CA 125, CA19.9, DUPAN-2, and TAG-72, and negative staining for CEA. Cytogenetic analysis showed chromosome 6 abnormalities similar to those found in OSPA. These results suggest that VSPA is a clinically aggressive primary tumor sharing morphological and cytogenetic analogy with OSPA.

Citations

Oct 18, 2001·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·W G McCluggageS P Dobbs
Feb 10, 2012·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Karen L TaliaW Glenn McCluggage
Dec 4, 2012·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Ciaran FlynnW Glenn McCluggage
May 5, 2016·BMC Women's Health·Sophie WarembourgArash Rafii

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