Primary signet-ring carcinoma (SRC) of the lung: a population-based epidemiologic study of 262 cases with comparison to adenocarcinoma of the lung

Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer
Sai-Hong I OuJason A Zell

Abstract

The presence of signet-ring cell component has been described as a prominent feature of EML4-ALK positive non-small cell lung cancer. We investigated the clinicopathologic features and survival outcome of primary signet-ring carcinoma (SRC) of the lung with comparison to adenocarcinoma of the lung. Retrospective population-based analysis of histologically diagnosed primary SRC of the lung in the California Cancer Registry between 1989 and 2006 with comparison with adenocarcinoma of the lung. Two hundred sixty-two histologically diagnosed primary SRC of the lung were compared to 50,089 patients with lung adenocarcinoma. Patients with primary SRC of the lung were significantly younger than patients with adenocarcinoma, with a significantly higher proportion of poorly differentiated tumor and stage IV disease. There was no difference in the distribution of gender and ethnicity among patients with SRC when compared to patients with adenocarcinoma. Subset analysis of patients with available smoking status revealed never smokers comprised a significantly higher proportion of patients with SRC (30.8%) when compared to patients with adenocarcinoma (11.0%; p = 0.0013). Never smokers with SRC tended to be younger with a trend to improved...Continue Reading

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Citations

Oct 2, 2012·Archives of Pathology & Laboratory Medicine·Philip T Cagle, Jeffrey Myers
Dec 18, 2012·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Jan H von der ThüsenAndrew G Nicholson
Dec 1, 2010·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Martin J Edelman
Jul 25, 2012·Pathology, Research and Practice·Takahiro MimaeHitoshi Tsuda
Aug 23, 2011·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Sanjay PopatAndrew G Nicholson
May 3, 2011·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Jitsuo UsudaNorihiko Ikeda
Nov 3, 2010·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Akihiko YoshidaTatsuhiro Shibata
Nov 16, 2010·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Jitsuo UsudaNorihiko Ikeda
Apr 21, 2016·Diagnostic Cytopathology·Archana George VallonthaielSudheer Arava
Jan 26, 2016·Applied Immunohistochemistry & Molecular Morphology : AIMM·Yihong R MaShi Wei
Jul 10, 2014·The American Journal of Surgical Pathology·Jennifer M BolandEunhee S Yi
Aug 20, 2020·Thoracic Cancer·Yi WangGuowei Che
Oct 18, 2011·Expert Review of Anticancer Therapy·Sai-Hong Ignatius OuMasanori Kitaichi
Jul 10, 2019·Case Reports in Obstetrics and Gynecology·Sabine DanzingerHeinz Kölbl
May 26, 2018·The Journal of the American Osteopathic Association·Michael CorviniUyen Nguyen
Sep 12, 2020·Respiratory Medicine Case Reports·Shamsuddin AnwarMaryam Rehan
Feb 18, 2021·Thoracic Cancer·Alberto TestoriUgo Cioffi
Apr 7, 2021·The Journal of Surgical Research·Maahum MehdiChandler S Cortina
Sep 23, 2021·Asian Cardiovascular & Thoracic Annals·Terrance PengAnthony W Kim

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