PMID: 8471633Apr 16, 1993Paper

Primary sites of actions of staurosporine and H-7 in the cascade of insulin action to glucose transport in rat adipocytes

Biochimica Et Biophysica Acta
Y YanoT Kono

Abstract

The insulin-stimulated glucose transporter in rat adipocytes was inhibited by two protein kinase inhibitors, staurosporine (SSP) and H-7 (1-(5-isoquinolinylsulfonyl)-2-methylpiperazine). However, whereas SSP (10 microM) blocked the insulin-dependent translocation of glucose transporter, H-7 (3 mM) did not. The latter inhibited glucose transporter activity not only in cells, but also in reconstituted liposomes. On the other hand, SSP blocked both the action of insulin and the insulinomimetic action of GTP gamma S (Guanosine 5'-O-(3-thiotriphosphate)). GTP gamma S had distinct effects on the glucose transport and cAMP phosphodiesterase (PDE) activities. It is suggest that H-7 may inhibit glucose transport activity per se; a SSP sensitive protein kinases (protein kinase C isoforms?) may be involved in cascade of the insulin action on glucose transporter as modulated by GTP gamma S; and glucose transport and PDE activities may be regulated by distinct GTP gamma S-sensitive factors.

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Citations

Jun 15, 1994·Molecular and Cellular Biochemistry·C BallardS Schaffer
Oct 11, 2012·Journal of Biomedicine & Biotechnology·Sandro M HirabaraRui Curi
Sep 20, 1996·The Journal of Biological Chemistry·J S MoyersC R Kahn
Nov 7, 2000·The Journal of Biological Chemistry·L LiH Shibata

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