PMID: 9433413Jan 1, 1997Paper

Primary Sjögren's syndrome associated with hyaline-vascular type of Castleman's disease and autoimmune idiopathic thrombocytopenia

Scandinavian Journal of Rheumatology
K HigashiH Nakamura

Abstract

We describe a case of primary Sjögren's syndrome complicated by hyaline-vascular type of Castleman's disease and autoimmune idiopathic thrombocytopenia. This type of Castleman's disease was diagnosed by biopsy of a right axillary lymph node 7 years after the onset of Sjögren's syndrome. The specimen showed small hyaline-vascular lymphoid follicles and interfollicular capillary proliferation. Serum IL-6 was slightly increased, but systemic manifestations, such as fever or weight loss, were not present. Hyaline-vascular type of Castleman's disease should be considered a lymphoproliferative disorder associated with Sjögren's syndrome.

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Citations

May 7, 2003·International Journal of Hematology·Akira TomonariShigetaka Asano
May 5, 2005·Current Treatment Options in Oncology·Angela Dispenzieri, Morie A Gertz
Nov 8, 2013·Case Reports in Hematology·Ruchi SoodHamed Daw
May 15, 2008·Pathology International·Takashi YuriAiro Tsubura
Dec 17, 2003·The British Journal of Dermatology·O V NikolskaiaG J Anhalt
Oct 9, 2002·The British Journal of Dermatology·D MimouniH C Nousari

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Castleman Disease

Castleman disease is a rare disorder that involves an overgrowth of cells in the lymph nodes. Unicentric Castleman disease affects one lymph node, usually in the chest or abdomen. Multicentric Castleman disease affects multiple lymph nodes, commonly located in the neck, collarbone, underarm and groin areas. Discover the latest research on Castleman disease here.