Primary Sjögren's syndrome: pathophysiological, clinical and therapeutic advances

Joint, Bone, Spine : Revue Du Rhumatisme
J-E Gottenberg

Abstract

Primary Sjögren's syndrome was long a vexing dilemma, as the underlying pathophysiological mechanisms remained obscure, disease activity was challenging to evaluate, and no specific treatments were known to be effective. However, recent years have witnessed major advances in these three areas. Convincing evidence has been obtained that innate immunity, most notably mediated by the interferons, plays a role in the initial B-cell activation. A disease activity score was developed during a consensus conference sponsored by the EULAR. Even more importantly, B-cell depletion constitutes a highly promising therapeutic approach. Thus, rituximab was effective in two controlled clinical trials.

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Jul 17, 2013·Nature Reviews. Rheumatology·Gaëtane Nocturne, Xavier Mariette
Aug 30, 2013·Medicina oral, patología oral y cirugía bucal·Antonio Bascones-MartinezJukka H Meurman
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Oct 19, 2017·Annals of Oncology : Official Journal of the European Society for Medical Oncology·D TeyssonneauA Italiano
Jun 9, 2021·Clinical and Experimental Medicine·Simone NegriniFrancesco Puppo

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