PMID: 6538144Feb 27, 1984Paper

Primary structure of a high Mr form of rat atrial natriuretic factor

FEBS Letters
G ThibaultM Chrétien

Abstract

During the purification of rat atrial natriuretic factor (ANF), low, intermediate and high Mr forms were observed. In this report we describe the purification and amino acid sequence of a 73 residue peptide containing at its C-terminus the previously sequenced 33 amino acid ANF peptide. The cleavage necessary to produce the 33 amino acid ANF from the 73 amino acid precursor occurs at a Leu-Leu bond. We also report the amino acid composition of an even longer form of ANF containing about 103 residues, in which the extension is amino terminal to the 73 peptide. A computer data bank search showed that the determined sequence is a novel one and is not homologous to any known proteins or segment thereof. The natriuretic activity of the 73 amino acid form when compared to that of a synthetic ANF peptide, comprising the sequence of the last 26 amino acids of ANF, was found to be slightly lower.

References

May 1, 1983·Canadian Journal of Biochemistry and Cell Biology = Revue Canadienne De Biochimie Et Biologie Cellulaire·C LazureS St-Pierre
Oct 31, 1983·Biochemical and Biophysical Research Communications·R T GrammerK S Misono

❮ Previous
Next ❯

Citations

Jan 1, 1985·Anatomy and Embryology·W G Forssmann, V Mutt
Dec 1, 1988·Cellular and Molecular Neurobiology·G Skofitsch, D M Jacobowitz
Nov 14, 1984·Biochemical and Biophysical Research Communications·K NakaoM Shimokura
Nov 15, 1985·Biochemical and Biophysical Research Communications·S OikawaH Matsuo
Mar 15, 1988·Clinica Chimica Acta; International Journal of Clinical Chemistry·L MeleagrosS R Bloom
May 13, 1985·Life Sciences·M B Anand-SrivastavaJ Genest
Jul 31, 1984·Biochemical and Biophysical Research Communications·J GutkowskaJ Genest
Oct 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·R A ZivinJ Drouin
May 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·N G SeidahT A Lyle
Nov 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·M NehlsW G Forssmann
Jan 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·R QuirionT V Dam
Jul 28, 1984·British Medical Journal·I H Mills
Oct 1, 1986·British Heart Journal·J Genest
Dec 1, 1985·The Journal of Clinical Investigation·B J Ballerman, B M Brenner
Jun 29, 1984·Biochemical and Biophysical Research Communications·D M GellerP Needleman
Jan 1, 1985·Clinical and Experimental Hypertension. Part A, Theory and Practice·T InagamiM Parmentier
Jan 1, 1984·Clinical and Experimental Hypertension. Part A, Theory and Practice·H Matsuo, K Kangawa
Jan 1, 1984·Clinical and Experimental Hypertension. Part A, Theory and Practice·W G ForssmannM Reinecke
Apr 16, 1985·Biochemical and Biophysical Research Communications·N KatsubeP Needleman
Dec 1, 1986·European Journal of Clinical Investigation·W G Forssmann
May 1, 1986·Journal of Neurochemistry·A FriedlB Hamprecht
Jun 21, 1984·Nature·G A Sagnella, G A MacGregor
Mar 15, 1985·Biochemical and Biophysical Research Communications·N MoriiH Imura
Aug 16, 1984·Biochemical and Biophysical Research Communications·B P KennedyP L Davies
Oct 30, 1984·Biochemical and Biophysical Research Communications·I TanakaT Inagami

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.