PMID: 7581334Sep 1, 1995Paper

Primary structure of the hydrogenosomal malic enzyme of Trichomonas vaginalis and its relationship to homologous enzymes

The Journal of Eukaryotic Microbiology
I Hrdý, Miklós Müller

Abstract

The complete nucleotide sequence has been established for two genes (maeA and maeB) coding for different subunits of the hydrogenosomal malic enzyme [malate dehydrogenase (decarboxylating) EC 1.1.1.39] of Trichomonas vaginalis. Two further genes (maeC and maeD) of this enzyme have been partially sequenced. The complete open reading frames code for polypeptides of 567 amino acids in length. These two open reading frames are similar with less than 12 percent pairwise nucleotide differences and less than 9 percent pairwise amino acid differences. The open reading frames of the two partially sequenced genes correspond to the amino-terminal part of the polypeptides coded and are similar to the corresponding parts of the completely sequenced ones. The deduced translation products of the two complete genes differ in their calculated pI values by 1.5 pH unit. The genes code for polypeptides which contain 12 or 11 amino-terminal amino-acyl residues not present in the proteins isolated from the cell. Other hydrogenosomal enzymes also have similar amino-terminal extensions which probably play a role in organellar targeting and translocation of the newly synthesized polypeptides. A comparison of 19 related enzymes from bacteria and eukaryo...Continue Reading

References

Jan 1, 1975·Current Topics in Cellular Regulation·R Frenkel
Dec 1, 1992·Trends in Biochemical Sciences·M W SmithR F Doolittle
Mar 1, 1992·Molecular and Biochemical Parasitology·D E Riley, J N Krieger
Apr 1, 1992·Molecular Microbiology·R ArroyoJ F Alderete
Aug 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·P J JohnsonM Müller
Dec 1, 1991·Current Opinion in Genetics & Development·M L Sogin
Nov 1, 1990·Journal of Molecular Evolution·R F DoolittleM R Alberro
Apr 1, 1989·European Journal of Biochemistry·G von HeijneR G Herrmann
Sep 1, 1989·Trends in Genetics : TIG·M W Gray
Jul 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·H MoriokaV M Nikodem
Jul 1, 1986·Molecular and Biochemical Parasitology·A Steinbüchel, M Müller
Jul 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·D DiMaioT Maniatis
Apr 1, 1984·Molecular and Biochemical Parasitology·A CerkasovováJ Kulda
Jan 1, 1994·Journal of Medical and Veterinary Mycology : Bi-monthly Publication of the International Society for Human and Animal Mycology·M C LeclercE Guého
Dec 1, 1993·Journal of General Microbiology·M Müller
May 10, 1994·Proceedings of the National Academy of Sciences of the United States of America·D V QuonP J Johnson
Mar 1, 1994·Plant Molecular Biology·T FushimiH Uchimiya
Nov 11, 1993·Nucleic Acids Research·H Philippe
Jan 1, 1993·Archives of Microbiology·F D Marvin-SikkemaR A Prins
Sep 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·W MartinR Cerff
Jan 1, 1993·Archives of Biochemistry and Biophysics·G KulkarniB G Harris
May 1, 1993·Molecular and Biochemical Parasitology·D D LeipeM L Sogin
Aug 1, 1991·Plant Physiology·J Van DoorsselaereD Inzé

❮ Previous
Next ❯

Citations

Feb 1, 1996·Molecular and Biochemical Parasitology·E T Bui, P J Johnson
Nov 25, 1996·Molecular and Biochemical Parasitology·L B SánchezM Müller
May 22, 2013·International Journal for Parasitology·Sven B GouldWilliam F Martin
Jun 14, 2002·International Journal for Parasitology·Siddhartha DasKrishna Reddy
Apr 3, 2003·International Journal for Parasitology·Stepanka VanacovaPatricia J Johnson
Apr 30, 1999·International Journal for Parasitology·J Kulda
Sep 16, 2000·Molecular and Biochemical Parasitology·C BakatselouC Graham Clark
Nov 6, 1998·Molecular and Biochemical Parasitology·G BricheuxG Brugerolle
Oct 17, 2006·Parasitology Today·D R Liston, P J Johnson
May 14, 1999·Parasitology Today·J Tachezy
Dec 10, 1996·Proceedings of the National Academy of Sciences of the United States of America·A GermotH Le Guyader
Dec 10, 1996·Proceedings of the National Academy of Sciences of the United States of America·A J RogerW F Doolittle
Jun 7, 2006·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·T Martin Embley
Feb 4, 2010·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Karin HjortT Martin Embley
Jun 13, 2012·Microbiology and Molecular Biology Reviews : MMBR·Miklós MüllerWilliam F Martin
Nov 15, 2011·International Journal for Parasitology·Rachel E SchneiderPatricia J Johnson
Jan 26, 2007·International Journal for Parasitology·Lena Burri, Patrick J Keeling
Jun 17, 2009·The Journal of Eukaryotic Microbiology·Mark van der Giezen
Jul 27, 2001·Molecular Biology and Evolution·D GerbodE Viscogliosi
Aug 10, 2000·Anais Da Academia Brasileira De Ciências·L B LópezF Costa e Silva Filho
Oct 29, 2004·Nature·Sabrina D DyallPatricia J Johnson
Sep 12, 2018·Trends in Parasitology·Herbert J SantosTomoyoshi Nozaki
Mar 28, 1998·Microbial Pathogenesis·J F AldereteJ L O'Brien

❮ Previous
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