Primary surgery versus primary radiation therapy for FIGO stages I-II small cell carcinoma of the uterine cervix: A retrospective Taiwanese Gynecologic Oncology Group study

Gynecologic Oncology
Tze-Chien ChenTing-Chang Chang

Abstract

To evaluate the role of surgery, radiation therapy and chemotherapy in the management of small cell carcinoma of the uterine cervix (SCCC) through a retrospective study of Taiwanese Gynecologic Oncology Group. We reviewed the medical records and histological files of 144 patients with FIGO stages IA-IIB SCCC treated in 11 main hospitals in Taiwan from 1987 to 2009. There were 110 patients receiving primary surgery and 34 primary radiation therapy. Most patients in each group also received chemotherapy as part of primary treatment. A lower loco-regional failure rate was observed in patients who received primary radiation therapy than in those who had primary surgery (6% vs. 27%; P=0.009). The 5-year overall survival (OS) was 89% for 13 surgically treated patients with cervical tumor ≤2cm and no lymphovascular space involvement (LVSI) in whom recurrence was noted in 2 of 4 patients without receiving adjuvant chemotherapy and none in the 9 patients who had chemotherapy. Excluding these 13 patients, primary radiation therapy with at least 5cycles of platinum-based chemotherapy (n=14, including 12 stages IB2-IIB) resulted in a 5-year OS of 78%, better than that of 46% by primary surgery (n=97, including 40 stages IB2-IIB) (P=0.046)....Continue Reading

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Citations

Dec 6, 2017·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Wei-Hsien HouYi-Jen Chen
Jun 3, 2018·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Li NingMei Yu
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Feb 6, 2021·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Won Kyung ChoJin Hwa Choi
Feb 11, 2021·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Gloria SalvoMichael Frumovitz

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