Abstract
Standard treatment of localized squamous cell carcinoma of the anus (SCCA) is radiotherapy (RT) combined with chemotherapy, that is, chemoradiation (CRT). Primary surgery has a limited role, but is a recommended treatment for small well differentiated SCCA localized in the anal margin, with re-excision or postoperative RT/CRT in case of involved surgical margins. The evidence supporting these strategies is limited. To study the recurrence patterns and survival outcomes in patients treated with surgery alone compared with surgery followed by postoperative RT/CRT. From a large Nordic database we identified 93 patients with stage TxT1-2N0M0 SCCA treated with surgery alone (n = 59) or surgery followed by RT/CRT (n = 34). Surgery consisted of local excision in 86 patients and abdominoperineal resection in seven patients, all of them in the surgery alone group. In 38 (41%) of the patients, the tumor was localized merely in the anal margin and in all remaining cases the anal canal was involved. Median RT dose to the tumor bed was 54 (range 46-66) Gy. Adjuvant RT to lymph nodes was given in 75% of the patients. Half of the patients received concomitant chemotherapy, usually 5-fluorouracil and mitomycin C. The locoregional recurrence (L...Continue Reading
References
Dec 1, 1989·International Journal of Colorectal Disease·S GoldmanE Ståhle
Jan 1, 1985·American Journal of Surgery·M J GreenallJ J DeCosse
May 1, 1974·Diseases of the Colon and Rectum·N D NigroB Considine
Jul 1, 1984·Cancer·B M BomanR J Spencer
Apr 1, 1983·Cancer·W H SchrautG E Block
Jul 1, 1994·Annals of Surgery·W E LongoF E Johnson
Mar 20, 1999·Journal of Surgical Oncology·K HuS H Quan
Jun 27, 2002·British Journal of Cancer·T BjørgeJ Dillner
May 14, 2005·International Journal of Radiation Oncology, Biology, Physics·Cécile OrtholanJean Pierre Gerard
Oct 9, 2007·International Journal of Radiation Oncology, Biology, Physics·Paul HatfieldDavid Sebag-Montefiore
Apr 24, 2008·JAMA : the Journal of the American Medical Association·Jaffer A AjaniChristopher Willett
Apr 25, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Didier PeiffertMichel Ducreux
Feb 27, 2013·Acta Oncologica·Anne Gry BentzenMarianne Grønlie Guren
Apr 13, 2013·The Lancet Oncology·Roger D JamesDavid Sebag-Montefiore
Jul 31, 2013·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Anne Gry BentzenLise Balteskard
Jul 9, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·R Glynne-JonesD Arnold
Dec 17, 2014·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Otilia LeonAnders Johnsson
Oct 20, 2017·JAMA Surgery·Christy Y ChaiNader N Massarweh
Citations
Oct 23, 2018·Acta Obstetricia Et Gynecologica Scandinavica·Vilma L JohnssonLine Rode
Sep 29, 2018·Acta Obstetricia Et Gynecologica Scandinavica·Gabriel Levin, Amihai Rottenstreich
Jan 29, 2019·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·A G RenehanUNKNOWN PLATO trial management group
Dec 12, 2019·The British Journal of Radiology·Kyung Su KimMi-Sook Kim
Sep 2, 2020·Diseases of the Colon and Rectum·Carmelina CappelloMayura Nathan
Sep 25, 2020·Diseases of the Colon and Rectum·J Michael Berry-Lawhorn
Jul 17, 2020·International Journal of Colorectal Disease·T B PedersenM F Klein
Nov 4, 2020·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·Tom A MaccabeDavid E Messenger
Sep 25, 2020·Diseases of the Colon and Rectum·Carmelina CappelloMayura Nathan
Apr 9, 2021·American Society of Clinical Oncology Educational Book·Rahel GhebreGypsyamber D'Souza
Apr 20, 2021·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Manon BacciVéronique Vendrely
Mar 23, 2020·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Xiang GaoImran Hassan