Primary thoracic extraskeletal osteosarcoma: a case report and literature review

Journal of Thoracic Disease
Jie QianHui-Min Wang

Abstract

Primary extraskeletal osteosarcoma (ESOS) presenting in thoracic locations is very rare and associated with a poor prognosis. The current study presents a case involving a large anterior mediastinal mass, which was histologically confirmed as a primary osteosarcoma. The literature concerning primary thoracic ESOS is reviewed. A total of 60 cases were identified. The median age was 60 years (range, 14-93 years) and males were more prevalent among the reported cases (65%). Survival analysis revealed that the overall 5-year survival was only 22.3%. The majority of cases of thoracic ESOS presented in the lung (n=24, 40%), with others presenting in the mediastinum, pleura, or chest wall. The benefit of surgery, chemotherapy and radiotherapy was confirmed by Cox regression survival analyses.

Citations

Aug 15, 2018·Clinical Nuclear Medicine·Zhen-Kui SunQuan-Yong Luo
Aug 14, 2019·The Korean Journal of Thoracic and Cardiovascular Surgery·Seohee JooChang Hyun Kang
May 22, 2021·Genes & Development·Rachelle R OlsenTrudy G Oliver
May 30, 2021·Advances in Anatomic Pathology·Joon Hyuk Choi, Jae Y Ro

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