Primary thymic extranodal marginal zone B cell lymphoma as an incidental finding in a Caucasian woman

BMJ Case Reports
Jeanette Krogh PetersenClaudia Stahlberg

Abstract

Primary thymic extranodal marginal zone B cell lymphoma (TML) is an extremely rare lymphoma strongly associated with autoimmune disease. We report an exceedingly rare case of TML found in a non-Asian population. TML was found incidentally in a 60-year-old Caucasian woman with a short history of muscle and joint pain. An anterior mediastinal mass was detected by a positron emission tomography-CT (PET-CT) scan and thymectomy was performed. The mass was contained within the thymus with a homogeneous pale cut surface with solid areas. Histologically, the typical morphological and immunophenotypic features of TML were found, with a prominent lymphoid infiltrate comprising of small-to-medium-sized neoplastic lymphocytes, plasmacytic differentiation and a distorted thymic epithelial network. Postoperative follow-up has indicated an associated undifferentiated connective tissue disease (UCTD) with features of systemic lupus erythaematosus.

Citations

Aug 26, 2021·Rheumatology International·Alexandra KobzaCatherine Ivory

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