Primary treatment endpoint following palliative radiotherapy for painful bone metastases: need for a consensus definition?

Clinical Oncology : a Journal of the Royal College of Radiologists
Jackson Sai-Yiu WuP Kirkbride

Abstract

To compare and contrast the definitions of primary treatment endpoints in randomized studies of dose-fractionation schedules for treating bone metastases and to identify basic characteristics of treatment endpoint that may require consensus among investigators. Randomized controlled trials (RCTs) of various dose-fractionation schedules for painful bone metastases, published between 1980 and 1999, and on-going trials whose protocols were available, were systematically reviewed based on the following features of the primary treatment endpoint: (i) degree of pain relief; (ii) timing of the pain response assessment; (iii) effect of co-interventions on pain relief; (iv) the reduction of analgesic as a treatment response; and (v) quantification of response duration. Ten published RCTs (each sampled over 100 patients), plus two current trial protocols were reviewed. Five of the 12 studies defined any reduction in pain score as the primary endpoint. Three trials defined response at pre-determined time points, whereas eight studies attributed pain improvement at any time during follow-up to the effect of radiotherapy. No trial incorporated effect of systemic treatments on response. Only two trials incorporated analgesic scores into the ...Continue Reading

Citations

May 31, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Thomas P ShakespeareChristopher J Wynne
Sep 26, 2003·Seminars in Surgical Oncology·Andrea Bezjak
Oct 5, 2010·The Cancer Journal·Stephen LutzBenjamin Corn
Oct 29, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Edward ChowMichael Brundage
Apr 2, 2017·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Kristopher DennisEdward Chow

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