Primary treatment of regional and disseminated pancreatic cancer with hexamethylmelamine, mitomycin C and 5-fluorouracil infusion

Oncology
H W BrucknerA McKenna

Abstract

Hexamethylmelamine, mitomycin C and 5-fluorouracil infusion (HexMF) achieved a median survival of 9 months for the 45 patients with either metastatic stage III or unresectable stage II carcinoma of the pancreas. Fifteen percent survived 2 years. Of 32 patients with measurable tumors, 7 had partial and 3 had minor responses (31%); an additional 44% has stable disease for 3 months or more. Response was associated with a 17-month median survival. These findings are indications for further evaluation of both dosage-intensive 5-fluorouracil infusions alone and HexMF as an alternative to streptozotocin- or adriamycin-containing regimens. Patients with nonmeasurable disease are candidates for survival-oriented phase III studies.

Citations

Jul 19, 2001·The Surgical Clinics of North America·A M Cooperman
Jul 19, 2001·The Surgical Clinics of North America·P KozuchH W Bruckner
Sep 19, 2000·Journal of Clinical Gastroenterology·A M CoopermanR S Chamberlain

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Ductal

Ductal carcinoma is a malignant neoplasm involving the ductal systems of any of a number of organs, such as the mammary glands, pancreas, prostate or lacrimal gland. Discover the latest research on ductal carcinoma here.

Related Papers

Diabetic Medicine : a Journal of the British Diabetic Association
D V Morris, J D Nabarro
Current Opinion in Clinical Nutrition and Metabolic Care
A M CoopermanR S Chamberlain
The Surgical Clinics of North America
J ShamsA M Cooperman
© 2022 Meta ULC. All rights reserved