Primary tumor resection in metastatic breast cancer: A propensity-matched analysis, 1988-2011 SEER data base

The Breast Journal
Nasreen VohraMahvish Muzaffar

Abstract

Primary tumor resection (PTR) in metastatic breast cancer is not a standard treatment modality, and its impact on survival is conflicting. The primary objective of this study was to analyze impact of PTR on survival in metastatic patients with breast cancer. A retrospective study of metastatic patients with breast cancer was conducted using the 1988-2011 Surveillance, Epidemiology, and End Results (SEER) data base. Cox proportional hazards regression models were used to evaluate the relationship between PTR and survival and to adjust for the heterogeneity between the groups, and a propensity score-matched analysis was also performed. A total of 29 916 patients with metastatic breast cancer were included in the study, and 15 129 (51%) of patients underwent primary tumor resection, and 14 787 (49%) patients did not undergo surgery. Overall, decreasing trend in PTR for metastatic breast cancer in last decades was noted. Primary tumor resection was associated with a longer median OS (34 vs 18 months). In a propensity score-matched analysis, prognosis was also more favorable in the resected group (P = .0017). Primary tumor resection in metastatic breast cancer was associated with survival improvement, and the improvement persisted i...Continue Reading

References

Aug 18, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Fabrice AndreMarc Spielmann
May 17, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Elisabetta RapitiChristine Bouchardy
Apr 29, 2008·Annals of Surgery·D Kay BlanchardRichard M Elledge
Jun 10, 2010·Annals of Oncology : Official Journal of the European Society for Medical Oncology·D Ali, R Le Scodan
Jun 30, 2011·Breast Cancer Research and Treatment·Laura DominiciMehra Golshan
Oct 29, 2011·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Z M RashaanG J Liefers
Oct 12, 2013·CA: a Cancer Journal for Clinicians·Carol DeSantisAhmedin Jemal
Jan 9, 2014·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
May 27, 2014·American Society of Clinical Oncology Educational Book·Linda R DuskaDon S Dizon
Dec 3, 2015·JAMA Surgery·Alexandra ThomasMary C Schroeder
Jan 6, 2017·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal

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Citations

Oct 6, 2018·The Breast Journal·Mahvish MuzaffarNasreen A Vohra
Feb 15, 2019·The Breast Journal·Nita S NairRajendra A Badwe
Jul 24, 2021·Indian Journal of Surgical Oncology·Gaurav PatelPrakash Patil

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