Primary tumor sidedness is an independent prognostic marker for survival in metastatic colorectal cancer: Results from a large retrospective cohort with mutational analysis

Cancer Medicine
Sophia C KamranTheodore S Hong

Abstract

Recent reports demonstrate inferior outcomes associated with primary right-sided vs left-sided colorectal tumors in patients with metastatic colorectal cancer (mCRC). We sought to describe our experience with mCRC patients on whom we have molecular data to determine whether primary tumor sidedness was an independent prognostic marker for overall survival (OS). mCRC patients with documented primary tumor sidedness who received mutational profiling between 2009 and 2014 were identified (n = 367, median follow-up 30.4 months). Mutational profiling for >150 mutations across commonly mutated cancer genes including RAS, PIK3CA, BRAF, and PTEN as well as treatment data, including receipt of a biologic agent, were collected. Univariable/multivariable models were used to analyze relationships between collected data and OS. Among 367 patients, sidedness breakdown was as follows: 234 left (64%), 133 right (36%). 56% were male, with a median age at diagnosis of 57 (range 24-89). A total of 143 patients had RAS mutations. Five-year OS was 41%, median OS was 54 months (range 1-149). Five-year OS for left- vs right-sided tumors was 46% vs 24% (P < .0001). On univariable analysis, among both RAS wildtype and mutant tumors, left-sided tumors co...Continue Reading

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Citations

Aug 11, 2018·European Journal of Nuclear Medicine and Molecular Imaging·E J van HeldenC W Menke-van der Houven van Oordt
Jan 17, 2019·Journal of Personalized Medicine·Jai N PatelMegan Jagosky
Jun 18, 2020·International Journal of Colorectal Disease·Kenichi MochizukiHideyuki Miyachi

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Methods Mentioned

BETA
genotyping
surgical resection

Clinical Trials Mentioned

NCT01978249

Software Mentioned

SAS
R

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