Primary versus Flap Closure of Perineal Defects following Oncologic Resection: A Systematic Review and Meta-Analysis

Plastic and Reconstructive Surgery
Chris DevulapalliGedge D Rosson

Abstract

Abdominoperineal resection and pelvic exenteration for resection of malignancies can lead to large perineal defects with significant surgical-site morbidity. Myocutaneous flaps have been proposed in place of primary closure to improve wound healing. A systematic review was conducted to compare primary closure with myocutaneous flap reconstruction of perineal defects following abdominoperineal resection or pelvic exenteration with regard to surgical-site complications. A comprehensive literature search was conducted using Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines in the MEDLINE, EMBASE, Google Scholar, and Cochrane Library databases. After data extraction from included studies, meta-analysis was performed to compare outcome parameters defining surgical-site complications of flap and primary closure. Our systematic review yielded 10 eligible studies (one randomized controlled trial and nine retrospective studies) involving 566 patients (226 flaps and 340 primary closures). Eight studies described rectus abdominis myocutaneous flaps and two studies used gracilis flaps. In meta-analysis, primary closure was more than twice as likely to be associated with total perineal wound complications compare...Continue Reading

References

Jan 1, 1992·The British Journal of Surgery·R Robles CamposJ Molina Martinez
Jul 1, 1990·Archives of Surgery·T TouranT X O'Connell
Jul 1, 1986·Journal of Surgical Oncology·N PetrelliA Mittelman
Oct 1, 1983·Annals of Surgery·S J MathesT K Hunt
Apr 1, 1980·Archives of Surgery·R S HartzT W Shields
Dec 1, 1995·Plastic and Reconstructive Surgery·C J GabkaT K Hunt
Feb 1, 1994·Plastic and Reconstructive Surgery·P G ArnoldP C Pairolero
Jul 29, 1998·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·S DelanianJ L Lefaix
Apr 14, 1999·The British Journal of Surgery·E RadiceL Gunderson
Jan 24, 2002·Diseases of the Colon and Rectum·A NissanA M Cohen
May 3, 2002·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·B C van der WalM A Choti
May 8, 2003·The British Journal of Surgery·T M TeiH Kjeldsen
Dec 17, 2003·Annals of Plastic Surgery·Edward Wayne BuchelCraig Johnson
Feb 5, 2005·Diseases of the Colon and Rectum·Laurent GhoutiJean-Robert Delpero
Feb 5, 2005·Diseases of the Colon and Rectum·Caprice K ChristianRonald Bleday
Oct 14, 2005·World Journal of Surgery·Floris T J FerenschildJohannes H W de Wilt
Oct 13, 2006·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·M A ChadwickA M Roe
Aug 2, 2007·Annals of Plastic Surgery·Paolo PersichettiRoberto Coppola
Apr 5, 2008·Journal of the American College of Surgeons·Charles E ButlerMiguel A Rodriguez-Bigas
Aug 9, 2008·International Journal of Colorectal Disease·Nicola PetrieHelen Chave
Dec 6, 2008·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·P J Nisar, H J Scott
Apr 4, 2009·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·S ChanM L George
Jul 15, 2009·Gynecologic Oncology·Jeffrey M Fowler
Oct 26, 2010·Journal of Gastrointestinal Cancer·Mark A BoccolaMatthew A Croxford
May 10, 2011·Diseases of the Colon and Rectum·Henrik Kidmose ChristensenSøren Laurberg
May 9, 2014·Diseases of the Colon and Rectum·John PangJustin M Sacks
Jun 26, 2014·Journal of Surgical Oncology·Ahmed TounyHamdy Elmarakby

❮ Previous
Next ❯

Citations

Apr 7, 2018·Diseases of the Colon and Rectum·Charnjiroj ThiptanakitChucheep Sahakitrungruang
Aug 17, 2018·Annals of Plastic Surgery·Umberto CortinovisFrancesco Raspagliesi
Nov 15, 2018·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·X Y YangZ Q Zhou
Apr 25, 2019·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·J A J CoelhoI R Daniels
May 23, 2019·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·R D BlokP J Tanis
Oct 9, 2019·Plastic and Reconstructive Surgery·Brielle WeinsteinJulian Pribaz
Jan 12, 2019·Annals of Plastic Surgery·Paige L MyersRonald P Bossert
Jan 6, 2019·International Journal of Colorectal Disease·G KoulaxouzidisF M Lampert
Jun 17, 2020·Plastic and Reconstructive Surgery. Global Open·Catherine M Westbom, Simon G Talbot
Jun 10, 2020·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Carlos Martínez-GómezGwenael Ferron
Jul 28, 2019·Plastic and Reconstructive Surgery·Christopher J CoroneosJames R Bain
Nov 30, 2019·Journal of Surgical Oncology·Gustavo A LaporteWilliam A Casteleins
May 23, 2020·Plastic and Reconstructive Surgery. Global Open·David PerraultArash Momeni
Oct 9, 2020·Microsurgery·Carlos OrdenanaBahar Bassiri Gharb
Nov 21, 2020·Diseases of the Colon and Rectum·César E CanessaRicardo Misa Jalda
Nov 21, 2020·Diseases of the Colon and Rectum·Y Nancy YouUNKNOWN On Behalf of the Clinical Practice Guidelines Committee of the American Society of Colon and Rectal Surgeons
Aug 26, 2020·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Katarina T WishartMario F Scaglioni
May 12, 2020·Journal of Minimally Invasive Gynecology·Rachael HaverlandJohnny Yi
Jan 19, 2021·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Matthew R ZeidermanLinda M Farkas
Mar 12, 2020·JPRAS Open·A O Wamalwa, S O Khainga
Jan 5, 2021·Diseases of the Colon and Rectum·Nishant Ganesh KumarTheodore A Kung
Apr 3, 2021·Surgical Oncology·Kheng-Seong Ng, Peter J M Lee
Apr 23, 2021·The American Surgeon·Olivia M DeLozierStephen W Behrman
Apr 28, 2021·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·Raymund E HorchAndreas Arkudas
Apr 24, 2021·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·David ChiSamuel J Lin
May 7, 2021·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Olivia SharpRichard Haywood

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Veterinary Surgery : VS
Virginia A GrigoropoulouAris F Pourlis
Geburtshilfe und Frauenheilkunde
W Köpcke
Journal of the Royal College of Surgeons of Edinburgh
L J de Souza, S R Shinde
© 2022 Meta ULC. All rights reserved