Primate Amygdalo-Nigral Pathway for Boosting Oculomotor Action in Motivating Situations

IScience
Kazutaka MaedaOkihide Hikosaka

Abstract

A primary function of the primate amygdala is to modulate behavior based on emotional cues. To study the underlying neural mechanism, we first inactivated the amygdala locally and temporarily by injecting a GABA agonist. Then, saccadic eye movements and gaze were suppressed only on the contralateral side. Next, we performed optogenetic activation after injecting a viral vector into the amygdala. Optical stimulation in the amygdala excited amygdala neurons, whereas optical stimulation of axon terminals in the substantia nigra pars reticulata inhibited nigra neurons. Optical stimulation in either structure facilitated saccades to the contralateral side. These data suggest that the amygdala controls saccades and gaze through the basal ganglia output to the superior colliculus. Importantly, this amygdala-derived circuit mediates emotional context information, whereas the internal basal ganglia circuit mediates object value information. This finding demonstrates a basic mechanism whereby basal ganglia output can be modulated by other areas conveying distinct information.

References

May 20, 1982·The Journal of Comparative Neurology·C R GerfenH C Fibiger
Aug 1, 1995·Perception & Psychophysics·J E Hoffman, B Subramaniam
Aug 28, 1998·Trends in Neurosciences·L W Swanson, G D Petrovich
Jul 14, 2000·Physiological Reviews·O HikosakaR Kawagoe
Mar 13, 2001·Molecular Psychiatry·M Davis, P J Whalen
May 8, 2002·Nature Reviews. Neuroscience·Maurizio Corbetta, Gordon L Shulman
Apr 4, 2003·Journal of Neurophysiology·Douglas P MunozKimberly D Moore
Nov 1, 1964·The Journal of Physiology·D A ROBINSON
Nov 24, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Masaharu YasudaOkihide Hikosaka
Nov 28, 2012·Neuron·Yoshihisa Tachibana, Okihide Hikosaka
Jul 5, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Shinya YamamotoOkihide Hikosaka
Dec 15, 2015·Nature Communications·Olga Dal MonteBruno B Averbeck
Nov 7, 2017·Journal of Affective Disorders·Rahel Bachem, Patricia Casey
Feb 9, 2018·Neuropsychiatric Disease and Treatment·Paulina Zelviene, Evaldas Kazlauskas
Mar 22, 2018·Proceedings of the National Academy of Sciences of the United States of America·Thomas A AvinoCynthia M Schumann
May 9, 2018·The European Journal of Neuroscience·Hidetoshi AmitaOkihide Hikosaka
Jun 6, 2018·PLoS Biology·Kazutaka MaedaOkihide Hikosaka
Jul 18, 2018·Proceedings of the National Academy of Sciences of the United States of America·Jessica TaubertLeslie G Ungerleider
Apr 16, 2020·Neuron·Elizabeth E SteinbergRobert C Malenka

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Citations

Jul 16, 2020·Journal of Neuroscience Methods·Adriana K CushnieSarah R Heilbronner
Oct 21, 2020·Neuron·Sébastien TremblayMichael L Platt

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