PMID: 8581369Oct 1, 1995Paper

Primate erythrocyte (E) complement receptor (CR1) as an anchor site for bispecific-based therapies to clear pathogens or autoantibodies safely from the circulation

Journal of Hematotherapy
R P Taylor, P J Ferguson

Abstract

We have prepared cross-linked, bispecific complexes [heteropolymers (HP) and antigen-based heteropolymers (AHP)] that facilitate complement-independent binding of target model pathogens or autoantibodies to primate erythrocytes (E) via complement receptors (CR1). The method is based on using monoclonal antibodies (mAb) specific for CR1 that either are cross-linked to an mAb specific for a prototype pathogen (e.g., IgE) or are cross-linked to an autoantigen (e.g., dsDNA) that is recognized by circulating pathogenic autoantibodies in the autoimmune disease systemic lupus erythematosus (SLE). The underlying assumption in this research is that complexed ligands containing IgG bound to primate E CR1 should be recognized and processed via the same mechanism by which complement-opsonized immune complexes bound to E CR1 are cleared from the circulation and phagocytosed in the liver and spleen. Our work in experimental monkey models has demonstrated that binding of substrates to primate E via this method does indeed lead to the safe and rapid clearance of the target pathogens or autoantibodies from the circulation, without any lysis or loss of the E. Although a number of questions must still be resolved, it may be possible to generalize...Continue Reading

References

Mar 8, 1979·The New England Journal of Medicine·M M FrankP H Plotz
Jul 1, 1992·Clinical and Experimental Immunology·W EmlenG Burdick
Mar 1, 1991·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·L A Hebert
Apr 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·R P TaylorR H Labuguen
Sep 1, 1989·The Journal of Clinical Investigation·R P KimberlyR P Taylor
Apr 1, 1989·Kidney International·J A Schifferli, R P Taylor
Apr 1, 1987·Kidney International·L A Hebert, G Cosio
Feb 1, 1983·The Journal of Clinical Investigation·J B CornacoffF J Waxman
Mar 1, 1995·Arthritis and Rheumatism·R P KimberlyJ C Edberg
Mar 23, 1994·Annals of the New York Academy of Sciences·O NilssonH Ahlman
Jun 6, 1994·Annals of the New York Academy of Sciences·J Bielski

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Citations

Aug 13, 1999·Clinical Immunology : the Official Journal of the Clinical Immunology Society·M L CraigR P Taylor
Jan 6, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·C S HahnR P Taylor

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