Oct 15, 1989

Primate spinothalamic pathways: III. Thalamic terminations of the dorsolateral and ventral spinothalamic pathways

The Journal of Comparative Neurology
A V Apkarian, C J Hodge

Abstract

The termination sites of the dorsolateral (DSTT) and ventral (VSTT) spinothalamic pathways were determined by using anterograde transport of horseradish peroxidase from the lumbar spinal cord in primates. One animal had no spinal cord lesion, while of two other animals, one received a midthoracic dorsolateral funiculus lesion, and the other received a midthoracic ventral quadrant lesion contralateral to the injection. The thalamic label in the animal with no spinal cord lesion was much less than the label in the two animals with spinal lesions. Moreover, in the animals with spinal lesions, HRP-labeled cells were found within the thalamus. Therefore, the remaining six animals received ipsilateral hemisections and bilateral dorsal column lesions, irrespective of the contralateral lesions. The thalamic label in the animals without contralateral lesions were assumed to represent the total spinothalamic input to the diencephalon. In these animals, label was located mainly in suprageniculate and pulvinar oralis, caudal and oral divisions of ventral posterior lateral nucleus, the lateral half of ventral posterior inferior nucleus, and zona incerta, while in the medial thalamus label was primarily in two distinct bands in medial dorsal...Continue Reading

Mentioned in this Paper

Alpha-Peroxidase
Biochemical Pathway
Entire Dorsomedial Nucleus of Thalamus
Dorsal Funiculus
Thalamic Nuclei
Entire Lumbar Spinal Cord
Spinothalamic Tracts
Wheat Germ Agglutinin Isolectin 2
Malignant Neoplasm of Spinal Cord
Bulla

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