Primers on molecular pathways: nuclear receptors in pancreatic cancer. The ligand-independent way

Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
Lucas P Nacusi, Jose D Debes

Abstract

Nuclear receptors (NRs) are ligand-activated transcription factors that regulate gene expression. These receptors share a quite similar structure and mechanism of action. Upon ligand binding, NRs translocate from the cytoplasm to the nucleus and bind to specific DNA sequences that regulate expression of different genes. In the absence of ligand the cascade of signaling events is different and either activation or repression may occur. Interestingly, several NRs are implicated in the pathogenesis of pancreatic cancer (PanCa). Specifically, androgen and estrogen receptor-related pathways are active in patients with pancreatic tumors, thus representing a suitable target for PanCa treatment. Although anti-hormone treatment has a modest effect on PanCa, ligand-independent activation of NRs remains overall unexplored in this disease.

References

Jul 14, 1998·Molecular Cell·Q ZhaoF Rastinejad
Dec 16, 1998·Clinica Chimica Acta; International Journal of Clinical Chemistry·P FogarM Plebani
Sep 14, 2001·Biochemical and Biophysical Research Communications·G EiblO J Hines
Sep 18, 2004·Circulation Research·Janice M Huss, Daniel P Kelly
Oct 8, 2004·The New England Journal of Medicine·Jose D Debes, Donald J Tindall
Mar 4, 2006·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun
Jul 27, 2006·Pancreas·Makoto SatakeGuido Eibl
Aug 8, 2006·Gastroenterology·Frédéric VarnatBéatrice Desvergne
Dec 2, 2006·Annual Review of Physiology·David L BainMichael T Miura
Jul 7, 2007·Physiological Reviews·Nina HeldringJan-Ake Gustafsson
Nov 21, 2007·FEBS Letters·Junichiro SonodaRonald M Evans
Jan 1, 2008·Molecular Endocrinology·Chenguang WangRichard G Pestell
Apr 19, 2008·Cold Spring Harbor Symposia on Quantitative Biology·X YangR M Evans
May 16, 2008·Journal of Internal Medicine·W Wahli

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