Primidone and phenobarbital during lactation period in epileptic women: total and free drug serum levels in the nursed infants and their effects on neonatal behavior

Developmental Pharmacology and Therapeutics
W KuhnzH Nau

Abstract

A total of 35 newborns whose mothers had been treated with either primidone (PMD), phenobarbital (PB) or a combination of one of these drugs with other antiepileptic drugs were included in this study. Fetal/maternal serum concentration ratios at birth, milk/serum concentration ratios and neonatal half-lives were determined for PMD, PB and phenylethylmalondiamide (PEMA). Steady-state serum levels of PMD in 2 nursed infants were 2.5 and 0.7 micrograms/ml, respectively, for PEMA values of 1.4 and 0.4 micrograms/ml. PB steady-state concentrations ranged between 2.0 and 13.0 micrograms/ml (6 infants). Maternal PB serum protein binding did not change during and after pregnancy. Neonatal free-fraction values at birth were similar to maternal values: 63.2 +/- 17.2% (n = 11). In the postnatal period, however, PB free-fraction values rose to more than 90% in some infants. In one case, neonatal free concentrations of PB were even higher during the 1st week after birth than the corresponding maternal values. Symptoms of sedation were observed in these neonates for which elevated free-fraction values of PB could be responsible. Behavior problems, such as withdrawal symptoms, were observed in neonates who eliminated PMD with short half-lives...Continue Reading

Citations

Dec 1, 1999·Journal of Human Lactation : Official Journal of International Lactation Consultant Association·S R Winkler
Jun 18, 2009·Current Opinion in Neurology·Anne Sabers, Torbjörn Tomson
Nov 25, 1998·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·J Bruni
Nov 28, 2006·Expert Opinion on Drug Metabolism & Toxicology·Gail D Anderson
Aug 11, 2000·Paediatric Drugs·B Bar-OzS Ito
Jul 13, 2000·The New England Journal of Medicine·S Ito
Jun 13, 2003·Clinical Pediatrics·Philip O AndersonAnthony S Manoguerra
Oct 8, 2014·British Journal of Clinical Pharmacology·D H van der MeerP G J Ter Horst
Apr 17, 1998·Journal of Human Lactation : Official Journal of International Lactation Consultant Association·L M Aleksy, M A Smith
Jul 6, 2000·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·S Hägg, O Spigset
Jun 13, 2016·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Irma ConvertinoMarco Tuccori
Jan 13, 2006·Therapeutic Drug Monitoring·Torbjörn Tomson
Mar 1, 2018·Der Nervenarzt·M CrettenandU Winterfeld
Sep 16, 2019·Seizure : the Journal of the British Epilepsy Association·Sonia MenonRobert Colebunders
Jun 14, 2002·Journal of Pharmaceutical and Biomedical Analysis·S Agatonovic-KustrinR G Alany
May 26, 2004·Pediatric Clinics of North America·Enrique M OstreaMaria Asuncion Silvestre

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