PMID: 11930108Apr 4, 2002Paper

Priming effects of GM-CSF, IFN-gamma and TNF-alpha on human neutrophil inflammatory cytokine production

Melanoma Research
E JabłońskaJ Jabłoński

Abstract

Identifying and evaluating the priming agents for cytokine release by neutrophils might be helpful in controlling the innate immune response of the host. In the present study we examined the role of granulocyte/macrophage colony-stimulating factor (GM-CSF), interferon-gamma (IFN-gamma) and tumour necrosis factor-alpha (TNF-alpha) as priming agents for interleukin (IL)-1beta, IL-6 and TNF-alpha production by stimulated neutrophils from control subjects and malignant melanoma patients. When the cells from controls and patients were preincubated with primer agents, opsonized zymosan-stimulated inflammatory cytokine production was enhanced. The major neutrophil-priming factor for IL-6 secretion by polymorphonuclear leukocytes (PMNs) in the control and patient groups was TNF-alpha. However, GM-CSF and IFN-gamma are also significant primers. GM-CSF priming was critical for the release of TNF-alpha from PMNs in control and melanoma patients. The ability of GM-CSF, IFN-gamma and TNF-alpha to serve as effective priming agents for inflammatory mediator production by PMNs revealed a new role for these cytokines in the innate immune response of the melanoma-bearing host.

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Citations

Aug 27, 2013·Archives of Dermatological Research·Simon GuérardPatrice E Poubelle
Feb 8, 2005·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Michael H KogutPete Kaiser
Nov 14, 2003·Proceedings of the National Academy of Sciences of the United States of America·Jian ChenDavid W Golde
Apr 21, 2004·Immunology·Terri N Ellis, Blaine L Beaman
Mar 2, 2018·Scientific Reports·Jee Hyun KimJoo Sung Kim
Apr 21, 2006·Journal of the American Society of Nephrology : JASN·Matthew David MorganCaroline Savage
Jun 10, 2020·International Wound Journal·Jiaoyun DongMing Tian
Aug 28, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Roland Csépányi-KömiErzsébet Ligeti
Jun 15, 2017·Frontiers in Cellular and Infection Microbiology·Irina MiraldaKenneth R McLeish
Oct 24, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Bryan HeitPaul Kubes
Nov 6, 2020·ImmunoTargets and Therapy·Kevin M C LeeJohn A Hamilton
Sep 11, 2018·Journal of Neuroimmunology·Milos KosticIvana Stojanovic

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