PMID: 7515521Mar 1, 1994Paper

Priming of HIV replication by tRNA(Lys3): role of reverse transcriptase

Trends in Biochemical Sciences
S LitvakL Tarrago-Litvak

Abstract

The fundamental role played by reverse transcriptase in the replication of retroviruses has stimulated the study of the mechanism of action of this enzyme. The reverse transcriptase of the type 1 human immunodeficiency virus forms a stable complex with its cognate transfer RNA replication primer (tRNA(Lys3)). Here, we outline the role of this enzyme in the selection of its primer tRNA, the annealing of primer tRNA to the complementary region of the retroviral genome, and the first attempts to use the reverse-transcriptase-tRNA complex as a new target for antiviral agents.

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Citations

Apr 1, 1996·Molecular Biotechnology·S Freeman, J M Gardiner
May 29, 2008·Journal of Computer-aided Molecular Design·Joseph RebehmedFrançois Maurel
Aug 5, 1996·Transfusion Science·S Joshi, R L Joshi
Nov 21, 2000·Trends in Biochemical Sciences·B Arezi, R D Kuchta
Mar 7, 2001·European Journal of Biochemistry·J F CabodevillaJ J Martínez-Irujo
Nov 8, 2006·Nucleic Acids Research·Jeffrey M Goodenbour, Tao Pan
Aug 12, 2005·Cytogenetic and Genome Research·F-X WilhelmA Gabriel
Nov 11, 1999·Antisense & Nucleic Acid Drug Development·I V MartyanovG A Nevinsky
Oct 5, 2019·Current Opinion in Structural Biology·Jan BergschGeorg Lipps
Oct 29, 1997·Journal of Virology·J Mak, L Kleiman

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