Priming protects the spinal cord in an experimental aortic occlusion model

The Journal of Thoracic and Cardiovascular Surgery
Hannu-Pekka HonkanenTatu Juvonen

Abstract

Paraplegia is a devastating complication in aortic aneurysm surgery. Modifying the spinal cord vasculature is a promising method in spinal cord protection. The aim of this study was to assess whether the spinal cord can be primed by occluding thoracic segmental arteries before simulated aneurysm repair in a porcine model. Twelve piglets were randomly assigned to the priming group (6) and the control group (6). Eight uppermost thoracic segmental arteries were occluded at 5-minute intervals in the priming group before a 25-minute aortic crossclamp. In the control group, the aorta was crossclamped for 25 minutes. During the first 5 minutes, 8 segmental arteries were occluded. After the aortic crossclamping, piglets were observed under anesthesia for 5 hours and followed up 5 days postoperatively. Near-infrared spectroscopy, motor-evoked potentials, blood samples, neurology with the modified Tarlov score, and histopathology of the spinal cord were assessed. The median Tarlov score during the first postoperative day was higher in the priming group than in the control group (P = .001). At the end, 50% of the control animals had paraplegia compared with 0% of paraplegia in the priming group. The mean regional histopathologic score dif...Continue Reading

References

Sep 1, 1994·The Annals of Thoracic Surgery·O E DapuntR B Griepp
Oct 30, 2003·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Justus T StrauchRandall B Griepp
Oct 26, 2006·The Annals of Thoracic Surgery·Christian D EtzRandall B Griepp
May 29, 2007·The Annals of Thoracic Surgery·Justus T StrauchRandall B Griepp
Jul 11, 2007·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Thomas N PajewskiLawrence H Phillips
Aug 28, 2007·The Annals of Thoracic Surgery·James C HalsteadRandall B Griepp
Feb 5, 2008·The Journal of Thoracic and Cardiovascular Surgery·Christian D EtzRandall B Griepp
Apr 1, 2008·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Christian D EtzRandall B Griepp
May 25, 2010·The Journal of Thoracic and Cardiovascular Surgery·Christian D EtzRandall B Griepp
Jul 9, 2010·The Annals of Thoracic Surgery·Fredrik S YannopoulosTatu Juvonen
Aug 25, 2010·The Annals of Thoracic Surgery·Stefano ZoliRandall B Griepp
Mar 23, 2011·The Journal of Thoracic and Cardiovascular Surgery·Christian D EtzRandall B Griepp
Mar 23, 2011·The Journal of Thoracic and Cardiovascular Surgery·Christian D EtzRandall B Griepp
Oct 13, 2011·Journal of Neurointerventional Surgery·Alejandro SantillanAthos Patsalides
Oct 1, 2013·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Philipp MeffertFabian A Kari
Nov 14, 2013·The Journal of Thoracic and Cardiovascular Surgery·Sarah GeisbüschGabriele Di Luozzo
Dec 3, 2014·Journal of Vascular Surgery·Adrian O'CallaghanMatthew J Eagleton
Aug 25, 2015·The Journal of Thoracic and Cardiovascular Surgery·Henri HaapanenTatu Juvonen
Feb 24, 2016·The Journal of Thoracic and Cardiovascular Surgery·Joseph S CoselliTodd K Rosengart
Sep 27, 2016·The Annals of Thoracic Surgery·Johanna HerajärviTatu Juvonen
Jan 4, 2017·Seminars in Thoracic and Cardiovascular Surgery·Fabian A KariFriedhelm Beyersdorf
Sep 29, 2017·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Fabian A KariFriedhelm Beyersdorf
Jul 4, 2018·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Daniela BranzanAndrej Schmidt
Jan 23, 2019·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Konstantin von AspernChristian D Etz
Apr 22, 2019·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Erin R LewisGabriele Di Luozzo
May 8, 2020·Seminars in Thoracic and Cardiovascular Surgery·Hannu-Pekka HonkanenTatu Juvonen

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