Priming stimulation enhances the effectiveness of low-frequency right prefrontal cortex transcranial magnetic stimulation in major depression

Journal of Clinical Psychopharmacology
Paul B FitzgeraldZafiris J Daskalakis

Abstract

Low-frequency, right-sided repetitive transcranial magnetic stimulation (rTMS) to the prefrontal cortex has been shown to have antidepressant effects. Recent research has suggested that preceding low-frequency rTMS with a period of low-intensity, 6-Hz stimulation ("priming") enhances the physiological effects of low-frequency stimulation. The aim of this study was to investigate whether priming stimulation would enhance therapeutic response to low-frequency rTMS in patients with depression. The study consisted of a 2-arm, double-blind, randomized, controlled trial in 60 patients with treatment-resistant depression. Right 1-Hz rTMS was provided in one continuous, 15-minute train to all subjects. The priming stimulation (twenty 5-second, 6-Hz trains) or an equivalent, sham preceded 1-Hz stimulation. The primary outcome variable was the score on the Montgomery-Asberg Depression Rating Scale (MADRS). There was a significant overall reduction in MADRS scores across the 4 weeks of the study and a significantly greater reduction in MADRS scores in the active-priming group compared with the sham-priming group. Low-intensity, high-frequency priming stimulation appears to enhance the response to low-frequency, right-sided rTMS treatment ...Continue Reading

References

Apr 1, 1979·The British Journal of Psychiatry : the Journal of Mental Science·S A Montgomery, M Asberg
Jul 1, 1990·The British Journal of Psychiatry : the Journal of Mental Science·G ParkerK Eyers
Mar 22, 2000·The Clinical Neuropsychologist·A M ShapiroJ Brandt
Nov 18, 2000·Biological Psychiatry·M S GeorgeJ C Ballenger
Dec 19, 2001·The Journal of Neuropsychiatry and Clinical Neurosciences·Z NahasM S George
Jul 2, 2002·The American Journal of Psychiatry·Ralph E Hoffman, Idil Cavus
Apr 23, 2003·Biological Psychiatry·Maurizio Fava
Jun 1, 1961·Archives of General Psychiatry·A T BECKJ ERBAUGH
Jun 19, 2004·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Alexander PeinemannHartwig Roman Siebner
Jan 26, 2006·Annals of Clinical Psychiatry : Official Journal of the American Academy of Clinical Psychiatrists·Keith IsenbergTheresa C Kormos
May 6, 2006·Journal of Applied Physiology·Gabrielle ToddMichael C Ridding
May 10, 2006·Experimental Brain Research·Zafiris J DaskalakisRobert Chen
Aug 8, 2006·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Paul B FitzgeraldZafiris J Daskalakis
Sep 9, 2006·The International Journal of Neuropsychopharmacology·Paul B FitzgeraldZ Jeff Daskalakis

❮ Previous
Next ❯

Citations

Jun 1, 2002·Ageing Research Reviews·Pietro GareriGiovambattista De Sarro
Mar 23, 2000·Progress in Neurobiology·P GareriG De Sarro
Aug 30, 2011·The Australian and New Zealand Journal of Psychiatry·Paul B Fitzgerald, Zafiris J Daskalakis
Nov 3, 2011·The Australian and New Zealand Journal of Psychiatry·Paul B Fitzgerald
Dec 14, 2011·Neurophysiologie clinique = Clinical neurophysiology·J-P LefaucheurL Garcia-Larrea
Aug 3, 2010·Postgraduate Medicine·Robert H Howland
Mar 14, 2012·Brain Stimulation·Martijn ArnsJ Leon Kenemans
Apr 17, 2010·La Revue de médecine interne·D SzekelyT Bougerol
May 5, 2009·Experimental Neurology·Frank Padberg, Mark S George
Mar 31, 2016·Neuroscience and Biobehavioral Reviews·D C W KloosterP Boon
Apr 10, 2016·Depression and Anxiety·Paul B FitzgeraldZafiris J Daskalakis
Jul 7, 2015·Revue D'épidémiologie Et De Santé Publique·F EtcheverrigarayA Sauvaget
Jul 19, 2014·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Jean-Pascal LefaucheurLuis Garcia-Larrea
Jan 12, 2017·Trends in psychiatry and psychotherapy·Renata de Melo Felipe, Ygor Arzeno Ferrão
Dec 3, 2011·Clinical Practice and Epidemiology in Mental Health : CP & EMH·Bernardo Dell'ossoA Carlo Altamura
Sep 26, 2012·Expert Review of Neurotherapeutics·Samar S AyacheJean-Pascal Lefaucheur
Jun 18, 2019·Clinical Pharmacology and Therapeutics·Alisson P Trevizol, Daniel M Blumberger
Jul 14, 2020·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Paul B FitzgeraldZafiris J Daskalakis
Sep 20, 2008·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Raymond W LamLakshmi N Yatham
Dec 22, 2009·Expert Review of Medical Devices·Rodrigo C L EdelmuthFelipe Fregni
May 1, 2018·Frontiers in Human Neuroscience·Wing Ting ToSven Vanneste
Dec 17, 2010·Expert Review of Medical Devices·Paul B Fitzgerald, Zafiris J Daskalakis
Jan 7, 2020·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Jean-Pascal LefaucheurUlf Ziemann

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.