Priming the tuberculosis drug pipeline: new antimycobacterial targets and agents

Current Opinion in Microbiology
Joanna C Evans, Valerie Mizrahi

Abstract

Claiming close to two million lives each year, tuberculosis is now the leading cause of death from an infectious disease. The rise in number of Mycobacterium tuberculosis (Mtb) strains resistant to existing TB drugs has underscored the urgent need to develop new antimycobacterials with novel mechanisms of action. To meet this need, a drug pipeline has been established that is populated with new and repurposed drugs. Recent advances in identifying molecules with inhibitory activity against Mtb under conditions modelled on those encountered during infection, and in elucidating their mechanisms of action, have primed the pipeline with promising drug/target couples, hit compounds and new targets. In this review, we highlight recent advances and emerging areas of opportunity in this field.

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Citations

Feb 2, 2019·Science·Valerie Mizrahi, Digby F Warner
Mar 10, 2020·ChemMedChem·Clinton G L Veale, Ronel Müller
May 7, 2020·Applied Microbiology and Biotechnology·Adetomiwa A AdenijiDu Toit Loots
Feb 11, 2020·Frontiers in Microbiology·Sarah D Riggs-ShuteZhaomin Yang
Sep 8, 2018·Proceedings of the National Academy of Sciences of the United States of America·Valerie Mizrahi, Digby F Warner
May 26, 2020·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Andrés-Felipe Villamizar-MogotocoroVladimir V Kouznetsov
Mar 16, 2021·Frontiers in Cellular and Infection Microbiology·Dilara Kiran, Randall J Basaraba
Feb 24, 2021·Antimicrobial Agents and Chemotherapy·Charles OmolloDigby F Warner
Jul 28, 2019·Microbiology Spectrum·Gabriel T MashabelaDigby F Warner
Dec 7, 2019·ACS Infectious Diseases·Manu De RyckerIan H Gilbert
Jul 31, 2019·Accounts of Chemical Research·Timothy J de WetValerie Mizrahi

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