Priming with rocuronium accelerates the onset of neuromuscular blockade

Journal of Clinical Anesthesia
K E GriffithS A Garg

Abstract

To investigate the effects of priming rocuronium on the time course of neuromuscular blockade. Prospective, controlled, randomized clinical study. University teaching hospital. 42 ASA physical status I and II patients undergoing peripheral surgery with general anesthesia. Following a standardized propofol-fentanyl induction, patients in Group 1 (n = 21) received a priming dose of rocuronium 0.06 mg/kg followed two minutes later by an intubating dose of rocuronium 0.54 mg/kg. Patients in Group 2 (n = 21) received a saline placebo injection followed two minutes later by rocuronium 0.6 mg/kg. Anesthesia was maintained with isoflurane and nitrous oxide 60% in oxygen. Neuromuscular function was assessed at the wrist using mechanomyography with a single-twitch mode of stimulation at a frequency of 1 Hz until tracheal intubation and at 0.1 Hz thereafter. The times from injection of the intubating dose of rocuronium until 95% suppression of the twitch tension (onset time), recovery of twitch tension to 25% of control (clinical duration of action), and the time from 25% to 75% spontaneous recovery of twitch tension (recovery index) were recorded. The trachea was intubated at 95% depression of the twitch tension and the intubating condit...Continue Reading

References

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Citations

Dec 31, 2004·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Joachim SchmidtSven Albrecht
Jul 3, 2007·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Matthias BockJohann Motsch
Jun 29, 2007·Der Anaesthesist·J SchmidtA Irouschek
Nov 13, 2009·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Pelin Traje TopcuogluSaadet Ozgen
Jan 7, 2000·Journal of Clinical Anesthesia·K DeepikaD B Martineau
Jan 4, 2001·Pediatric Emergency Care·K A Doobinin, T A Nakagawa
Feb 18, 2014·Acta Anaesthesiologica Taiwanica : Official Journal of the Taiwan Society of Anesthesiologists·Navid NooraeiSeyed Amir Mohajerani
Dec 23, 2008·Journal of Clinical Anesthesia·Jae Moon ChoiKyung Don Hahm
Jan 11, 2000·Emergency Medicine Clinics of North America·P S Wadbrook
Jun 16, 2005·Acta Anaesthesiologica Scandinavica·Y LeykinA Gullo
Mar 20, 2010·Acta Anaesthesiologica Scandinavica·M TsuchiyaA Asada
Jul 13, 2002·European Journal of Anaesthesiology·B YavaşcaoğluO Kutlay
Jul 28, 1999·Anesthesiology·H Kirkegaard-NielsenP D Berry

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