Priming with rocuronium accelerates the onset of neuromuscular blockade

Journal of Clinical Anesthesia
K E GriffithS A Garg


To investigate the effects of priming rocuronium on the time course of neuromuscular blockade. Prospective, controlled, randomized clinical study. University teaching hospital. 42 ASA physical status I and II patients undergoing peripheral surgery with general anesthesia. Following a standardized propofol-fentanyl induction, patients in Group 1 (n = 21) received a priming dose of rocuronium 0.06 mg/kg followed two minutes later by an intubating dose of rocuronium 0.54 mg/kg. Patients in Group 2 (n = 21) received a saline placebo injection followed two minutes later by rocuronium 0.6 mg/kg. Anesthesia was maintained with isoflurane and nitrous oxide 60% in oxygen. Neuromuscular function was assessed at the wrist using mechanomyography with a single-twitch mode of stimulation at a frequency of 1 Hz until tracheal intubation and at 0.1 Hz thereafter. The times from injection of the intubating dose of rocuronium until 95% suppression of the twitch tension (onset time), recovery of twitch tension to 25% of control (clinical duration of action), and the time from 25% to 75% spontaneous recovery of twitch tension (recovery index) were recorded. The trachea was intubated at 95% depression of the twitch tension and the intubating condit...Continue Reading


Jan 1, 1992·Journal of Clinical Anesthesia·A F Ghouri, P F White
Jul 1, 1991·Acta Anaesthesiologica Scandinavica·L I ErikssonC Lennmarken
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Aug 1, 1988·Anaesthesia·K McKeatingJ W Dundee
Oct 1, 1994·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·M Naguib

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