PMID: 9525607Apr 3, 1998Paper

Priming with secreted glycoprotein G of respiratory syncytial virus (RSV) augments interleukin-5 production and tissue eosinophilia after RSV challenge

Journal of Virology
T R JohnsonB S Graham

Abstract

The respiratory syncytial virus (RSV) G glycoprotein promotes differentiation of type 2 CD4+ T lymphocytes and induces an eosinophilic response in lungs of RSV-infected mice. A unique feature of G is that a second initiation codon in the transmembrane region of the glycoprotein results in secretion of soluble protein from infected cells. Recombinant vaccinia viruses that express wild-type G (vvWT G), only secreted G (vvM48), or only membrane-anchored G (vvM48I) were used to define the influence of G priming on immunopathogenesis. Mice immunized with vvM48 had more severe illness following RSV challenge than did mice primed with vvWT G or vvM48I. Coadministration of purified G during priming with the construct expressing membrane-anchored G shifted immune responses following RSV challenge to a more Th2-like response. This was characterized by increased interleukin-5 in lung supernatants and an increase in G-specific immunoglobulin G1 antibodies. Eosinophils were present in the infiltrate of all mice primed with G-containing vectors but were greatest in mice primed with regimens including secreted G. These data suggest the form of G protein available for initial antigen processing and presentation is an important factor in promot...Continue Reading

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Citations

Nov 4, 2000·American Journal of Respiratory Cell and Molecular Biology·F E BarrV L Shepherd
Jul 5, 2005·Expert Opinion on Investigational Drugs·R Weltzin
Sep 23, 2006·Expert Review of Vaccines·Sandra ThomasSuresh Mahalingam
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Jul 16, 2005·Expert Opinion on Biological Therapy·Martin Cranage, Geraldine Taylor

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