Primitive nervous systems: action of aminergic drugs and blocking agents on activity in the ventral nerve cord of the flatworm Notoplana acticola

Journal of Neurobiology
L KeenanK Bernardo

Abstract

Electrically evoked activity in the submuscular ventral longitudinal nerve cords of Notoplana acticola is depressed by GABA and glycine in the presence of high magnesium concentrations. This inhibition occurs with 0.001--0.01 millimolar concentrations of these putative aminergic neurotransmitters and is reversible when washed out. The action of GABA and glycine was reversed nonspecifically by picrotoxin, bicuculline, and strychnine. PTZ (Pentylenetetrazole) was shown to mimic the effects that these blocking agents had on evoked activity when they were tested alone. The release of inhibition by these blocking agents is similar to that of decerebration. Three possible mechanisms responsible for synaptic activity in high Mg2+ concentrations are discussed and the possibility that the effector site of interaction may be the chloride ionophore is explored.

References

Apr 1, 1995·Parasitology·K S ErikssonC Shaw
Mar 30, 2006·Parasitology·P RibeiroN Patocka
Nov 1, 1985·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·H B Sarnat, M G Netsky

Related Concepts

Neurons
Picrotoxin
Perineurium
Potentials, Event-Related
Neurohormones
Platyhelminthes
Gamma-Aminobutyric Acid, Zinc Salt (2:1)
Pentazol
Glycine, Sodium Hydrogen Carbonate
Bicuculline

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