Primordial odontogenic tumor: Subepithelial expression of Syndecan-1 and Ki-67 suggests origin during early odontogenesis

Oral Diseases
R Bologna-MolinaA Mosqueda-Taylor

Abstract

Primordial odontogenic tumor (POT) is composed of variably cellular myxoid connective tissue, surrounded by cuboidal to columnar odontogenic epithelium resembling the inner epithelium of the enamel organ, which often invaginates into the underlying connective tissue. The tumor is delimited at least partially by a thin fibrous capsule. It derives from the early stages of tooth development. Syndecan-1 is a heparan sulfate proteoglycan that has a physiological role in several cellular functions, including maintenance of the epithelial architecture, cell-to-cell adhesion and interaction of cells with extracellular matrix, and with diverse growth factors, stimulating cell proliferation. Ki-67 is considered the gold standard as a cell proliferation marker. The aim of this study was to examine the expression of Syndecan-1 and Ki-67 proliferation index in POT and normal tooth germs to better understand the biological behavior of this tumor. Results showed that Syndecan-1 was more intensely expressed in subepithelial mesenchymal areas of POT, in a pattern that resembles the early stages of tooth development. The cell proliferation index (4.1%) suggests that POT is a slow growing tumor. Syndecan-1 expression in tooth germs in late cap an...Continue Reading

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Citations

Jun 17, 2018·Oral Diseases·Toshinari MikamiYasunori Takeda
Sep 24, 2019·Histopathology·Ronell Bologna-Molina, Adalberto Mosqueda-Taylor
Jun 11, 2019·Case Reports in Dentistry·Lucas Novaes TeixeiraVera Cavalcanti de Araújo
Mar 21, 2018·Head and Neck Pathology·Bianca Bravim BomfimMário José Romañach
Mar 8, 2020·Journal of Stomatology, Oral and Maxillofacial Surgery·L AzziV Maurino
Sep 29, 2020·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Wilson A Delgado-AzañeroAdalberto Mosqueda-Taylor

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