PrimPol is required for replication reinitiation after mtDNA damage

Proceedings of the National Academy of Sciences of the United States of America
Rubén Torregrosa-MuñumerJaakko L O Pohjoismäki

Abstract

Eukaryotic PrimPol is a recently discovered DNA-dependent DNA primase and translesion synthesis DNA polymerase found in the nucleus and mitochondria. Although PrimPol has been shown to be required for repriming of stalled replication forks in the nucleus, its role in mitochondria has remained unresolved. Here we demonstrate in vivo and in vitro that PrimPol can reinitiate stalled mtDNA replication and can prime mtDNA replication from nonconventional origins. Our results not only help in the understanding of how mitochondria cope with replicative stress but can also explain some controversial features of the lagging-strand replication.

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Jul 30, 2017·International Journal of Molecular Sciences·Elizaveta O BoldinovaAlena V Makarova
Jul 13, 2018·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Jaakko L O PohjoismäkiSjoerd Wanrooij
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