Principal Component Analysis of Tissue Scores from Substances used in the COLIPA Eye Irritation Validation Study

Toxicology in Vitro : an International Journal Published in Association with BIBRA
D P Lovell

Abstract

Principal component analyses (PCA) have been carried out on the tissue scores from Draize eye irritation tests on the 55 formulations and chemical ingredients included in the COLIPA Eye Irritation Validation Study. A PCA was carried out on the tissue scores 24, 48 and 72 hours after instillation of the substances. The first Principal Component (PC I) explained 77% of the total variation in the tissues scores and showed a high negative correlation (r=-0.971) with the scores used to derive the Modified Maximum Average Score (MMAS). The second component (PC II) explained 7% of the total variability and contrasted corneal and iris damage with conjunctival damage as in a similar analysis carried out previously on the ECETOC databank. The third component (PCIII), while only explaining about 3% of the variability, identified individuals treated with formulations that were observed to have low corneal opacity but large corneal area scores. This may represent some particular manner of scoring at the laboratory administering the Draize test or a specific effect of some formulations. A further PCA was carried out on tissue scores from observations at 1hr to 21 days. PC I in this analysis explained 62% of the variability and there was a hi...Continue Reading

References

Jan 1, 1997·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·P FederJ Springer
Dec 1, 1995·Toxicology in Vitro : an International Journal Published in Association with BIBRA·M BallsH Spielmann
Oct 1, 1996·Toxicology in Vitro : an International Journal Published in Association with BIBRA·D P Lovell
Feb 1, 1997·Toxicology in Vitro : an International Journal Published in Association with BIBRA·P G BrantomM Stern
Nov 1, 1992·Toxicology in Vitro : an International Journal Published in Association with BIBRA·D M BagleyA P Walker

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Citations

Jan 7, 2003·Alternatives to Laboratory Animals : ATLA·Ludwig A Hothorn
Dec 15, 2004·Alternatives to Laboratory Animals : ATLA·Lutz Edler, Carina Ittrich

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