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Principal components analysis corrects for stratification in genome-wide association studies

Nature Genetics

Aug 1, 2006

Alkes L. PriceDavid E. Reich

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Abstract

Population stratification--allele frequency differences between cases and controls due to systematic ancestry differences-can cause spurious associations in disease studies. We describe a method that enables explicit detection and correction of population stratification on a genome-wide...read more

Mentioned in this Paper

Single Nucleotide Polymorphism
Genome-Wide Association Study
GenBank
Principal Component Analysis
Genetic Markers
Genome, Human
Alleles
Genomics
Nested Case-Control Studies
36
1
1
3199
1
2
Paper Details
References
  • References29
  • Citations3427
12345...

Principal components analysis corrects for stratification in genome-wide association studies

Nature Genetics

Aug 1, 2006

Alkes L. PriceDavid E. Reich

PMID: 16862161

DOI: 10.1038/ng1847

Abstract

Population stratification--allele frequency differences between cases and controls due to systematic ancestry differences-can cause spurious associations in disease studies. We describe a method that enables explicit detection and correction of population stratification on a genome-wide...read more

Mentioned in this Paper

Single Nucleotide Polymorphism
Genome-Wide Association Study
GenBank
Principal Component Analysis
Genetic Markers
36
1
1
3199
1
2
Paper Details
References
  • References29
  • Citations3427
12345...

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