PMID: 6540231Jul 1, 1984Paper

Principal components analysis of haematological data from F344 rats with bladder cancer fed N-(ethyl)-all-trans-retinamide

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
M F FestingR M Hicks

Abstract

Several multivariate statistical methods are available which can alleviate the problems of analysing the large volumes of data generated from toxicological experiments. One such technique, principal components analysis, provides a method for exploring the relationships between a number of variables (such as blood parameters) and for eliminating redundant data if strong correlations exist between the characters. It also provides a method for clustering individuals, which may reveal similarities between animals in a treatment group or highlight individual 'outliers'. The application of principal components analysis to a set of haematological data from a trial evaluating the efficacy of a synthetic retinoid against carcinogen-induced bladder cancer in the rat has clearly shown, in two bivariate plots, that while some animals in the carcinogen-treated groups were normal, others were anaemic and that animals fed the synthetic retinoid and killed at 1 year had a microcytic anaemia. A full exploration of the data using conventional univariate statistical analysis would have involved at least 28 graphic representations of the data, as well as the interpretation of more than 130 means and SDs. Principal components analysis provides a va...Continue Reading

References

Oct 11, 1969·The Veterinary Record·G H Townsend
Dec 1, 1971·Journal of Clinical Pathology·H R MillarA L Stalker
Aug 23, 1969·The Veterinary Record·G H Townsend
Jul 1, 1980·Journal of Toxicology and Environmental Health·L e Gray, J W Laskey

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Citations

Apr 11, 2001·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·M F FestingJ A Turton
Jul 8, 2010·Circulation Journal : Official Journal of the Japanese Circulation Society·Erquan ZhangKazuo Maruyama
Apr 1, 1985·Medical Informatics = Médecine Et Informatique·D P Lovell

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