PMID: 9450688Feb 5, 1998Paper

Principal involvement of cyclooxygenase-1-derived prostaglandins in the c-fos expression of the rat hind brain following visceral stimulation with acetic acid

Brain Research. Molecular Brain Research
H KusuharaT Okumoto

Abstract

We investigated the relationship between c-fos expression in the hind brain and peritoneal prostaglandin (PG) synthesis after visceronociceptive stimulation with acetic acid in rats. Time-course studies on the mRNA expression for c-fos in the hind brain and cyclooxygenase (COX) isoforms in the peritoneal cells, as well as on the peritoneal 6-keto-PGF1alpha accumulation, after stimulation indicated that COX-1 but not COX-2 was responsible for the peritoneal synthesis of PGs which were suggested to evoke c-fos expression in the hind brain. Pharmacological experiments using mofezolac, a preferential inhibitor against COX-1, and NS-398, a selective inhibitor against COX-2, confirmed the involvement of COX-1 derived PGs in the induction of c-fos expression in the hind brain following the noxious stimulation.

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Citations

Jul 16, 2002·Brain Research. Molecular Brain Research·T H J BurneC L Gilbert
Sep 2, 1998·Proceedings of the National Academy of Sciences of the United States of America·M NakayamaS H Graham
Nov 20, 2014·ACS Medicinal Chemistry Letters·Md Jashim UddinLawrence J Marnett
Jan 17, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Nobuhito TanakaIkuo Morita
Dec 1, 1998·Journal of Clinical Pharmacology·Francesc CabréDavid Mauleón

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