PMID: 16537990Mar 16, 2006Paper

Principle and clinical usefulness of the infrared fluorescence endoscopy

The Journal of Medical Investigation : JMI
Susumu ItoYoshimitsu Nagao

Abstract

Since there is no infrared fluorescence materials in the living body, infrared fluorescence labeling materials are very useful for making a diagnosis of a micro cancer. We have developed an infrared fluorescence endoscope (IRFE) and indocyanin green (ICG)-derivative as infrared fluorescence labeling materials to evaluate gastrointestinal neoplastic lesions. The study aims were to apply an IRFE and to demonstrate its usefulness in detecting cancerous tissue using an antibody coupled with ICG-derivative. IRFE consisted of an infrared endoscope equipped with excitation (710-790 nm) and barrier (810-920 nm) filters and an intensified CCD camera. We have developed ICG N-hydroxy sulfo succinimide ester (ICG-sulfo-OSu) and 3-ICG-acyl-1, 3-thiazolidine-2-thione (ICG-ATT) as an infrared fluorescent-labeling reagent. ICG-derivative-labeled mouse anti-human carcinoembryonic antigen (CEA) antibody and MUC1 antibody were employed in this study. Moreover, we examined the ability of a reinforcement agent, octylglucoside, to intensity fluorescence from the labeled antibody. Biopsy specimens of gastric cancer were stained with anti-CEA antibody by the avidin-biotinylated peroxidase complex method. Among the positive specimens, freshly resected ...Continue Reading

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Citations

Nov 12, 2009·Future Oncology·Nobuyuki KosakaHisataka Kobayashi
Jul 29, 2010·Nanomedicine·Nobuyuki KosakaHisataka Kobayashi
Jan 11, 2011·World Journal of Gastroenterology : WJG·Monalisa FilipTudorel Ciurea
Nov 8, 2012·Journal of Pharmaceutical Sciences·Ahu YuanYiqiao Hu
May 9, 2009·Gastrointestinal Endoscopy Clinics of North America·Meng Li, Thomas D Wang
Sep 21, 2007·Surgical Oncology·Steven C Cunningham, Richard D Schulick
Jun 27, 2007·Gastrointestinal Endoscopy·Tetsuo KimuraEiji Kudo
Aug 25, 2015·IEEE Transactions on Biomedical Circuits and Systems·Panayiota DemosthenousJulius Georgiou
Apr 23, 2019·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Chinyere Charity EzeanyaCharlotte Oguejiofor
Apr 17, 2019·Nature Reviews. Gastroenterology & Hepatology·Gerard CumminsAnastasios Koulaouzidis
Oct 7, 2020·The Journal of Law, Medicine & Ethics : a Journal of the American Society of Law, Medicine & Ethics·Jamila K Taylor

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