Principles for identification of High Potency Category Chemicals for which the Dermal Sensitisation Threshold (DST) approach should not be applied

Regulatory Toxicology and Pharmacology : RTP
D W RobertsJon F Lalko

Abstract

An essential step in ensuring the toxicological safety of chemicals used in consumer products is the evaluation of their skin sensitising potential. The sensitising potency, coupled with information on exposure levels, can be used in a Quantitative Risk Assessment (QRA) to determine an acceptable level of a given chemical in a given product. Where consumer skin exposure is low, a risk assessment can be conducted using the Dermal Sensitisation Threshold (DST) approach, avoiding the need to determine potency experimentally. Since skin sensitisation involves chemical reaction with skin proteins, the first step in the DST approach is to assess, on the basis of the chemical structure, whether the chemical is expected to be reactive or not. Our accompanying publication describes the probabilistic derivation of a DST of 64 μg/cm(2) for chemicals assessed as reactive. This would protect against 95% of chemicals assessed as reactive, but the remaining 5% would include chemicals with very high potency. Here we discuss the chemical properties and structural features of high potency sensitisers, and derive an approach whereby they can be identified and consequently excluded from application of the DST.

References

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Citations

Sep 19, 2015·Regulatory Toxicology and Pharmacology : RTP·David W RobertsLambros Kromidas
May 3, 2015·Regulatory Toxicology and Pharmacology : RTP·Robert J SaffordJon F Lalko
Sep 11, 2016·Regulatory Toxicology and Pharmacology : RTP·David Basketter, Bob Safford
Jan 26, 2017·Chemical Research in Toxicology·David W RobertsAnne Marie Api
Jan 11, 2019·The Journal of Toxicological Sciences·Taku NishijoHitoshi Sakaguchi
Mar 5, 2019·Dermatitis : Contact, Atopic, Occupational, Drug·Andrew D MonnotDerek A Drechsel
Jun 27, 2019·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A M ApiS Tsang
Dec 20, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A M ApiY Tokura
Jan 1, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A M ApiS Tsang
Dec 20, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·G SullivanY Tokura
Aug 20, 2019·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A M ApiS Tsang
Jan 20, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A M ApiY Tokura
Jan 19, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A M ApiY Tokura
Jan 19, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A M ApiY Tokura
Jan 20, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A M ApiS Tsang
Jan 19, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A M ApiY Tokura
Jan 19, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A M ApiY Tokura
Feb 12, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A M ApiY Tokura
Feb 13, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A M ApiS Tsang
Feb 12, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A M ApiY Tokura
Jan 31, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A M ApiY Tokura
Feb 11, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A M ApiY Tokura
Feb 11, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A M ApiY Tokura
Feb 11, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A M ApiY Tokura
Feb 11, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A M ApiY Tokura
Feb 17, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A M ApiY Tokura
Jan 19, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A M ApiY Tokura
Mar 7, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A M ApiS Tsang
Mar 3, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A M ApiY Tokura
Mar 3, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A M ApiY Tokura
Mar 6, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A M ApiY Tokura
Mar 18, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A M ApiY Tokura
Mar 18, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A M ApiY Tokura
Mar 18, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A M ApiY Tokura
Mar 17, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A M ApiY Tokura
Mar 30, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A M ApiY Tokura
Mar 29, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A M ApiY Tokura
Apr 9, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A M ApiY Tokura
Apr 10, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A M ApiY Tokura
Nov 21, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A M ApiY Tokura
Nov 22, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A M ApiY Tokura
Nov 30, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A M ApiY Tokura
Dec 4, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A M ApiY Tokura
Dec 5, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A M ApiY Tokura
Dec 5, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A M ApiY Tokura
Dec 6, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A M ApiY Tokura
Dec 12, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A M ApiY Tokura
Apr 13, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A M ApiY Tokura

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