journal cover

Principles Governing A-to-I RNA Editing in the Breast Cancer Transcriptome

Cell Reports

Oct 7, 2015

Debora FumagalliVincent Detours

Abstract

Little is known about how RNA editing operates in cancer. Transcriptome analysis of 68 normal and cancerous breast tissues revealed that the editing enzyme ADAR acts uniformly, on the same loci, across tissues. In controlled ADAR expression experiments, the editing frequency increased a...read more

Mentioned in this Paper

Tumor Cells, Uncertain Whether Benign or Malignant
Subfamily lentivirinae
Gene Dosage
ADAR
Apoptosis, Intrinsic Pathway
Neoplastic Cell
Neoplasms
Transduction
Gene Amplification Technique
Cell Proliferation
20
170
Paper Details
References
  • References49
  • Citations41
12345
  • References49
  • Citations41
12345

Similar Papers Found In These Feeds

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Epigenome Engineering

Recent advances in epigenome engineering technologies allow now for the large-scale assessment of the functional relevance of dna methylation. Discover the latest research here.

Interferon Signalling

Via interaction with their specific receptors, interferons (IFNs) activate signal transducer and activator of transcription (STAT) complexes. STAT activation initiates the classical Janus kinase-STAT (JAK-STAT) signaling pathway. In this pathway, JAKs associate with IFN receptors and, following receptor engagement with IFN, phosphorylate both STAT1 and STAT2. As a result, an IFN-stimulated gene factor 3 (ISGF3) complex forms—this contains STAT1, STAT2 and a third transcription factor called IRF9—and moves into the cell nucleus. Inside the nucleus, the ISGF3 complex binds to specific nucleotide sequences called IFN-stimulated response elements (ISREs) in the promoters of certain genes, known as IFN stimulated genes. Discover the latest research on interferon signalling here.

RNAi & Gene Silencing

RNA Interference (RNAi) pathway is involved in post-transcriptional gene silencing, transcriptional silencing and epigenetic silencing as well as its use as a tool for forward genetics and therapeutics. Discover the latest research here.

Human Cell Atlas Consortium

The aim of the Human Cell Atlas is to build reference maps of all human cells in order to enhance our understanding of health and disease. Follow the latest research from the Human Cell Atlas Consortium here.

Interferon Stimulated Genes

Interferon-stimulated gene products take on a number of diverse roles. Collectively, they are highly effective at resisting and controlling pathogens. Discover the latest research on interferon-stimulated genes here.

CZI Human Cell Atlas Seed Network

The aim of the Human Cell Atlas (HCA) is to build reference maps of all human cells in order to enhance our understanding of health and disease. The Seed Networks for the HCA project aims to bring together collaborators with different areas of expertise in order to facilitate the development of the HCA. Find the latest research from members of the HCA Seed Networks here.

Hormone-Related Cancers

This feed focuses on hormone-related cancers including cancer of the breast, endometrium, ovary, prostate, testis, thyroid, and bone, all of which share unique mechanisms of carcinogenesis. Here is the latest research.

RNA Editing and ADAR Enzymes

ADAR enzymes are responsible for a-to-i rna editing, an essential post-transcriptional rna modification contributing to transcriptome and proteome diversification.

Human Cell Atlas - CZI seed networks

The Human Cell Atlas aims to create reference maps of all human cells in order to enhance our understanding of health and disease. Follow the latest research from Seed Networks grantees for the Human Cell Atlas.

Human Tumor Atlas

The Human Tumor Atlas is a collaborative project that uses detailed maps of a variety of cancers to investigate cancer development, metastasis, and treatments.

Inflammation & Cancer

Inflammation has been implicated in initiation and progression of tumors, as well as elimination of cancerous cells. Here is the latest research on the role of inflammation in cancer.

International Cancer Genome Consortium

The International Cancer Genome Consortium (ICGC) was founded with the goal of mapping the genome of 25,000 primary untreated cancers. The ICGC has also pushed for the global sharing of genomic data to facilitate cancer research. Find the latest research from the ICGC here.

RNA Binding Proteins

This feed focuses on RNA Binding Proteins, which are involved in post-transcriptional processes, such as alternative splicing, RNA transport, localization and function.

Epigenome Engineering (Keystone)

Recent advances in epigenome engineering technologies allow now for the large-scale assessment of the functional relevance of DNA methylation. Discover the latest research here.

Related Papers

Drug Discovery Today

Abundant A-to-I editing in the human transcriptome

Drug Discovery TodaySeptember 24, 2004
Nicole Johnston
Progress in Nucleic Acid Research and Molecular Biology

ADAR gene family and A-to-I RNA editing: diverse roles in posttranscriptional gene regulation

Progress in Nucleic Acid Research and Molecular BiologyAugust 13, 2005
Louis Valente, Kazuko Nishikura
© 2020 Meta ULC. All rights reserved

Principles Governing A-to-I RNA Editing in the Breast Cancer Transcriptome

Cell Reports

Oct 7, 2015

Debora FumagalliVincent Detours

PMID: 26440892

DOI: 10.1016/j.celrep.2015.09.032

Abstract

Little is known about how RNA editing operates in cancer. Transcriptome analysis of 68 normal and cancerous breast tissues revealed that the editing enzyme ADAR acts uniformly, on the same loci, across tissues. In controlled ADAR expression experiments, the editing frequency increased a...read more

Mentioned in this Paper

Tumor Cells, Uncertain Whether Benign or Malignant
Subfamily lentivirinae
Gene Dosage
ADAR
Apoptosis, Intrinsic Pathway
Neoplastic Cell
Neoplasms
Transduction
Gene Amplification Technique
Cell Proliferation
20
170

Similar Papers Found In These Feeds

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Related Papers

Drug Discovery Today

Abundant A-to-I editing in the human transcriptome

Drug Discovery TodaySeptember 24, 2004
Nicole Johnston
Progress in Nucleic Acid Research and Molecular Biology

ADAR gene family and A-to-I RNA editing: diverse roles in posttranscriptional gene regulation

Progress in Nucleic Acid Research and Molecular BiologyAugust 13, 2005
Louis Valente, Kazuko Nishikura
Paper Details
References
  • References49
  • Citations41
12345
  • References49
  • Citations41
12345
/papers/principles-governing-a-to-i-rna-editing-in-the/26440892