Principles of Leukocyte Migration Strategies.

Trends in Cell Biology
Petra Kameritsch, Jörg Renkawitz

Abstract

Migration of leukocytes is essential for the induction, maintenance, and regulation of immune responses. On their trafficking routes, leukocytes encounter microenvironments of diverse mechanochemical composition, such as epithelial sheets, fibrillar networks, and cell-dense lymphatic organs. These microenvironments impose fundamental challenges on leukocytes, which include adhesive crawling under high shear stress, extreme cellular deformation while crossing physical barriers, and pathfinding in maze-like 3D environments. Crossing these microenvironments in a fast and efficient manner is a hallmark of leukocyte biology. We review the underlying cell biological principles and molecular mechanisms. By integrating knowledge from physiological in vivo and reductionistic in vitro approaches, we developed a holistic view of leukocyte migration strategies, including misregulation in disease and mechanistic hijacking by tumor cells.

Citations

Jan 13, 2021·Biomaterials Science·Adrienne E WidenerEdward A Phelps
Feb 26, 2021·Nature Reviews. Immunology·Deborah J Fowell, Minsoo Kim
Apr 13, 2021·Biochemical Society Transactions·Jaehyun LeeEsak Lee
May 1, 2021·Cancers·Yang ZhaoJennifer Gamble
Jun 19, 2021·Drug Delivery·Yong-Jiang LiDa-Xiong Xiang
Jul 13, 2021·Frontiers in Cell and Developmental Biology·Anne AaltoErez Raz
Jul 23, 2021·Biophysics Reviews·Doriane VesperiniFranziska Lautenschläger
Aug 14, 2021·Journal of Nanobiotechnology·Yong-Jiang LiDa-Xiong Xiang
Aug 27, 2021·Current Opinion in Cell Biology·Ana-Maria Lennon-Duménil, Hélène D Moreau

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