Principles of magnetic resonance assessment of brain function

Journal of Magnetic Resonance Imaging : JMRI
David G Norris

Abstract

MRI has advanced to being one of the major tools for the assessment of brain function. This review article examines the basic principles that underpin these measurements. The main emphasis is on the characteristics and detection of blood oxygen level dependent (BOLD) contrast. In the first part of the article the relationship between BOLD, blood flow, blood oxygen, and the rate of metabolic consumption of oxygen is described. The four contrast mechanisms that contribute to the BOLD signal change, namely extravascular static and dynamic dephasing, intravascular T2-like changes, and the intravascular frequency offset effect are described in terms of their spatial localization and relative contributions to the BOLD signal. The current model of changes in blood flow being an indirect consequence of synaptic input to a region is presented. The second section of the article deals with the imaging characteristics of BOLD in terms of the attainable spatial resolution and linear system characteristics. In the third section, practical BOLD imaging is examined for choice of pulse sequence, resolution, echo time (TE), repetition time (TR), and flip angle. The final section touches on other MRI approaches that are relevant to cognitive neur...Continue Reading

References

Dec 1, 1992·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·C H MeyerA Macovski
Jan 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·D S WilliamsA P Koretsky
Dec 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·S OgawaD W Tank
Apr 1, 1990·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·S OgawaP Glynn
Jun 1, 1990·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·J W BelliveauT J Brady
Apr 1, 1988·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·J FrahmW Hänicke
Feb 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·P T Fox, M E Raichle
Jul 18, 1995·Proceedings of the National Academy of Sciences of the United States of America·P van GelderenC T Moonen
Jul 1, 1995·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·J L BoxermanR M Weisskoff
Jul 1, 1995·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·P Jezzard, R S Balaban
Dec 1, 1994·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·D A Yablonskiy, E M Haacke
Jun 16, 1994·Nature·S A EngelM N Shadlen
Jan 1, 1994·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·J HennigE Feifel
Jan 1, 1994·Biophysical Journal·P J BasserD LeBihan
Dec 1, 1993·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·G LiuC T Moonen
Sep 1, 1993·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·R S MenonK Uğurbil
Jan 1, 1993·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·J FrahmW Hänicke
Oct 1, 1995·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·B BiswalJ S Hyde
Feb 1, 1996·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·J FrahmA Kleinschmidt
Feb 1, 1996·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·A W SongJ S Hyde
Jun 1, 1996·Radiology·P JezzardR S Balaban
Mar 1, 1996·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·K J FristonR Turner
Jun 1, 1996·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·S G KimK Uğurbil
Jan 1, 1997·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R B Buxton, L R Frank
Nov 5, 1997·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·D K Sodickson, W J Manning
Jan 23, 1998·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·K J FristonR Turner
Jan 23, 1998·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·S Lai, G H Glover
Mar 14, 1998·Proceedings of the National Academy of Sciences of the United States of America·B R RosenA M Dale
Apr 16, 1998·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·J B MandevilleR M Weisskoff
Jun 11, 1998·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·R B BuxtonL R Frank
Jul 11, 1998·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·R A JonesD P Auer
Aug 4, 1998·Journal of Applied Physiology·F HyderD L Rothman
Dec 3, 1998·Experimental Brain Research·R TurnerK Friston
Feb 9, 1999·Human Brain Mapping·R M BirnR Shaker
May 8, 1999·Journal of Magnetic Resonance Imaging : JMRI·J P WansapuraW S Ball
Jun 12, 1999·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J B MandevilleR M Weisskoff
Jul 10, 1999·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·S PosseV G Kiselev
Jul 21, 1999·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·F CalamanteR Turner
Aug 4, 1999·Proceedings of the National Academy of Sciences of the United States of America·R D HogeG B Pike
Aug 31, 1999·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·O Josephs, R N Henson

❮ Previous
Next ❯

Citations

Dec 24, 2008·European Journal of Nuclear Medicine and Molecular Imaging·Ewald MoserMark E Ladd
May 13, 2010·European Journal of Nuclear Medicine and Molecular Imaging·Petros MartirosianFritz Schick
Dec 13, 2012·European Journal of Applied Physiology·Marianne B HavnesAndreas Møllerløkken
Jan 10, 2009·The American Journal of Bioethics : AJOB·William Ball, Scott Holland
Sep 7, 2011·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·I BojakRolf Kötter
Nov 22, 2008·Journal of Biomedical Optics·Theodore J HuppertDavid A Boas
Apr 25, 2012·BMC Medical Imaging·Zikuan Chen, Vince Calhoun
Jan 28, 2014·PloS One·Gigi Galiana, R Todd Constable
Nov 22, 2011·Reviews in the Neurosciences·Craig F FerrisMarcelo Febo
Jul 21, 2011·World Journal of Clinical Oncology·Domenico ZacaJay J Pillai
Jan 14, 2010·Computational Intelligence and Neuroscience·Dilek Göksel Duru, Mehmed Ozkan
Dec 3, 2014·Neuroimaging Clinics of North America·Domenico ZacàJay J Pillai
Jul 17, 2012·Hematology/oncology Clinics of North America·Bart P Keogh, John W Henson
Apr 13, 2012·Magnetic Resonance Imaging·Abby Y DingEd X Wu
Sep 16, 2011·Magnetic Resonance Imaging·Daniel PflugfelderTony Stöcker
Mar 1, 2011·Brain Research Reviews·Hong PanEmily Stern
Dec 6, 2008·Neurologic Clinics·Michael E MoseleyThomas Brosnan
Dec 10, 2008·Neuroimaging Clinics of North America·A L MacKayC Laule
Oct 22, 2008·Hand Clinics·Dimitri J AnastakisDavid Mikulis
Jan 12, 2008·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Hiroshi Shibasaki
Nov 13, 2007·Neurophysiologie clinique = Clinical neurophysiology·S Fall, G de Marco
Jan 5, 2011·The European Journal of Neuroscience·Ana CatarinoHoward Ring
Mar 12, 2013·Neurourology and Urodynamics·Stasa D TadicDerek Griffiths
May 28, 2011·NMR in Biomedicine·Yohan van de LooijHana Lahrech
Apr 8, 2010·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Markus BarthDavid G Norris
Mar 1, 2013·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Juliane BuddeRolf Pohmann
Feb 8, 2013·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·D J HollandS D Beyea
Oct 7, 2015·Frontiers in Behavioral Neuroscience·Craig F FerrisC Sue Carter
Jul 16, 2015·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Mayur NarsudeJosé P Marques
Jul 14, 2012·Magnetic Resonance Imaging·Noam Ben-EliezerLucio Frydman
Apr 18, 2012·NeuroImage·Shiori AmemiyaKuni Ohtomo
Feb 9, 2010·NeuroImage·B A PoserM Barth
Nov 20, 2009·Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group on Motor Neuron Diseases·Dorothée LuléJan Kassubek
Aug 1, 2007·Expert Opinion on Drug Discovery·Michael J Minzenberg, Cameron S Carter
Apr 20, 2013·Functional Neurology·Mauricio MandelGerson Chadi
Sep 16, 2011·Epilepsy Research·Giridhar P KalamangalamPonnada A Narayana
Sep 29, 2011·NeuroImage·Christian Schwarzbauer, Ralf Deichmann

❮ Previous
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