Principles of nuclear medicine imaging: planar, SPECT, PET, multi-modality, and autoradiography systems

Radiation Research
Pat Zanzonico

Abstract

The underlying principles of nuclear medicine imaging involve the use of unsealed sources of radioactivity in the form of radiopharmaceuticals. The ionizing radiations that accompany the decay of the administered radioactivity can be quantitatively detected, measured, and imaged in vivo with instruments such as gamma cameras. This paper reviews the design and operating principles, as well as the capabilities and limitations, of instruments used clinically and preclinically for in vivo radionuclide imaging. These include gamma cameras, single-photon emission computed tomography (SPECT) scanners, and positron emission tomography (PET) scanners. The technical basis of autoradiography is reviewed as well.

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Citations

May 9, 2014·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Daniele de Paula FariaErik de Vries
Aug 11, 2015·International Journal of Endocrine Oncology·Jessica E Maxwell, James R Howe
May 27, 2014·Bioconjugate Chemistry·Christian BrandThomas Reiner
Nov 28, 2015·Surgical Oncology Clinics of North America·Jessica E MaxwellJames R Howe
Oct 13, 2015·Frontiers in Neuroendocrinology·Anat Biegon
Mar 24, 2016·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Edwin C PrattJan Grimm
Aug 20, 2015·EJNMMI Research·Andreas PaulusWolfgang A Weber
Mar 20, 2015·Drug Delivery and Translational Research·James T Cole, Nolan B Holland
Oct 21, 2016·Multiple Sclerosis : Clinical and Laboratory Research·Laura AirasJuha Rinne
Oct 13, 2016·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Maria GeorgiouGeorge Loudos
Jan 8, 2019·Nuclear Medicine Communications·Issa Loutfi
Apr 11, 2019·Journal of Labelled Compounds & Radiopharmaceuticals·Nourihan S FarragOla A Abdel Moamen
Feb 15, 2020·Nanotechnology·Maia Mombrú FrutosIvana Aguiar
Sep 12, 2013·Biomedizinische Technik. Biomedical Engineering·Julia FreseFabian Kiessling
Oct 21, 2016·Physics in Medicine and Biology·Alexandra ZverevaMarkus Schwaiger
Jan 20, 2021·Seminars in Cancer Biology·Vladimir TolmachevJens Sörensen
Dec 30, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Maxime MunchGilles Ulrich
Oct 31, 2020·Stroke and Vascular Neurology·Xiaoxia YangXia Meng
May 1, 2021·International Journal of Molecular Sciences·Sara S RinneVladimir Tolmachev

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Methods Mentioned

BETA
X-
or
-ray
X-ray
transgenic
xenograft

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