Jan 9, 1996

Principles of protein-protein interactions

Proceedings of the National Academy of Sciences of the United States of America
S Jones, J M Thornton

Abstract

This review examines protein complexes in the Brookhaven Protein Databank to gain a better understanding of the principles governing the interactions involved in protein-protein recognition. The factors that influence the formation of protein-protein complexes are explored in four different types of protein-protein complexes--homodimeric proteins, heterodimeric proteins, enzyme-inhibitor complexes, and antibody-protein complexes. The comparison between the complexes highlights differences that reflect their biological roles.

  • References40
  • Citations1328

Mentioned in this Paper

Structure-Activity Relationship
Complex (molecular entity)
Crystallography, X-Ray
Plasma Protein Binding Capacity
Protein Conformation
Immune complex
Hydrogen Bonding
Protein Conformation, beta-Strand

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