Principles of selective inactivation of viral genome. VIII. The influence of beta-propiolactone on immunogenic and protective activities of influenza virus

Vaccine
E I BudowskyS F Shenderovich

Abstract

The influence of beta-propiolactone action on the immunogenic and protective activity of the influenza virus A/WSN/33 (H1N1) has been studied. The production of antibodies against virion surface antigens in mice immunized intramuscularly by the modified virus was enhanced with the increase of inoculating dose from 6 x 10(7) to 1.5 x 10(8) viral particles per animal. The immunizing dose of 6 x 10(7) produced complete protection of immunized animals against a lethal challenge of A/WSN/33 virus. The inhibition of virus reproduction in animal lungs was increased with the increase of the virus immunizing dose up to 6 x 10(8). At a constant dose the inhibition of virus reproduction decreases with the increase of the virus modification extent.

References

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Citations

Mar 14, 2008·Pharmaceutical Research·J-P AmorijW L J Hinrichs
Jan 30, 2004·Virus Research·Yuri A SmirnovNikolai V Kaverin
Aug 30, 2008·Journal of Fish Diseases·E AndersonS LaPatra
May 11, 2013·Expert Review of Vaccines·Celene Salgado-MirandaGary García-Espinosa
Oct 22, 2013·Biochimica Et Biophysica Acta·Pierre BonnafousOlivier Lambert
Jan 22, 2015·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·A Sally DavisJeffery K Taubenberger
Jul 25, 2019·Reviews in Medical Virology·Ailar SabbaghiAmir Ghaemi
Jun 11, 2020·Viruses·Alexander S JurekaChristopher F Basler
Feb 21, 2021·Journal of Clinical Laboratory Analysis·Helena CeruttiAlessandra Brogi

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