Principles of the therapeutic use of monoclonal antibodies in oncology

Comptes rendus biologies
Wolf H Fridman

Abstract

Monoclonal antibodies have reached the stage of therapeutic agents, mostly in oncology, as illustrated by their wide use in lymphoma, breast cancer or colorectal cancer. The unravelling of their mechanisms of action and their interactions with their cellular receptors allows us to engineer new classes of therapeutic antibodies with increased efficacy. The identification of some of the tumour escape mechanisms may also help to define new approaches for patient selection and immunomonitoring. The present review addresses these various aspects.

References

Apr 15, 2004·Immunology Letters·Joël F G Cohen-SolalCatherine Sautès-Fridman
Dec 24, 2005·The New England Journal of Medicine·Franck PagèsJérôme Galon

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