Printed Combinatorial Sensors for Simultaneous Detection of Ascorbic Acid, Uric Acid, Dopamine, and Nitrite

ACS Omega
Chun-Hao SuYing-Chih Liao

Abstract

In this study, an effective and simple direct printing method was developed to create sensing devices on screen-printed carbon electrodes (SPCEs) to detect multiple species simultaneously. Two sensing materials, graphene oxide nanoribbons (GONRs) and poly(3,4-ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS), were printed on one SPCE for detection of multiple biochemical substances. Printed layers of the GONRs and PEDOT:PSS mixture (GONRs & PEDOT:PSS) on SPCE showed embedment of GONRs in the PEDOT:PSS layer and diminished the electrochemical activity of GONRs. In contrast, by printing the GONRs and PEDOT:PSS at separate locations (GONRs + PEDOT:PSS) on the same SPCE, the electrochemical activities of both GONRs and PEDOT:PSS can be preserved. Thus, without synthesizing new materials, the modified electrode is able to simultaneously detect ascorbic acid (AA), uric acid (UA), dopamine (DA), and nitrite (NO2-), with high anodic oxidation currents and well-separated voltammetric peaks, in differential pulse voltammetry measurements. The detection limits for the four analytes are 41 nM (AA), 30 nM (DA), 11 nM (UA), and 18 nM (NO2-), respectively. The electrode can either detect single species separately or simultaneously det...Continue Reading

References

Sep 22, 1992·European Journal of Pharmacology·G LonartK M Johnson
Feb 1, 1994·Journal of Neurochemistry·R Guevara-GuzmanK M Kendrick
Jun 1, 1993·Journal of Neuroscience Research·G LonartK M Johnson
Sep 10, 2014·Biosensors & Bioelectronics·Chia-Liang SunJhing-Jhou Wu

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Citations

Jul 13, 2019·Critical Reviews in Analytical Chemistry·Qiangwei WangJinming Kong
Jul 31, 2020·Biosensors & Bioelectronics·Valentin SaunierAli Maziz
Dec 8, 2020·ACS Chemical Neuroscience·Sasya MadhurantakamUma Maheswari Krishnan

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Methods Mentioned

BETA
biosensor
scanning electron microscopy

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